Genomic interactions with disease and nutrition

Paoloni-Giacobino, Ariane; Grimble, Robert F.; Pichard, Claude

doi:10.1016/s0261-5614(03)00091-8

Cited by 31 publications

(13 citation statements)

References 54 publications

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“…Patients with heterozygocity in these alleles, coding for moderate cytokine production, were termed the intermediate phenotype, whereas patients with homozygocity for low generation of cytokines were called the low‐producing phenotype. The rationale for dichotomizing the allele distribution into high and low producing genotypes is described previously [15].…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms in cytokine genes influence long‐term survival differently in elderly male and female patients

Cederholm

Persson

Andersson

et al. 2007

Journal of Internal Medicine

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Abstract. Cederholm T, Persson M, Andersson P, Stenvinkel P, Nordfors L, Madden J, Vedin I, Wretlind B, Grimble RF, Palmblad J (Uppsala University Hospital, Sweden; University of Southampton School of Medicine, Southampton, UK; and Karolinska University Hospital, Stockholm, Sweden). Polymorphisms in cytokine genes influence long-term survival differently in elderly male and female patients. J Intern Med 2007; 262: 215-223.Objectives. We asked if single nucleotide polymorphisms (SNP) in inflammatory cytokine genes related to 3-year survival in ill elderly subjects and if genotypes differed between the elderly and a younger control population.Design. Prospective observational study.Setting. Two geriatric departments at a university hospital.Subjects. Eighty three acutely admitted geriatric patients (83 ± 7 year, 70% women) and 207 young healthy subjects (40 ± 1 year, 37% women) were included.Outcome measures. Single nucleotide polymorphisms in the genes of tumour necrosis factor (TNF)-a -308 G/A, interleukin (IL)-1b -511 C/T, IL-6 -174 G/C and IL-10 -1082 A/G were analysed. In the geriatric patients SNP in lymphotoxin (LT)-a +252 G/A and serum levels of TNF-a, IL-6, IL-10, soluble IL-I receptor(R)II were also determined, as well as the 3-year mortality.Results. The allele distribution did not differ significantly between the elderly and the young. In the female elderly, 3-year survival was doubled (P < 0.05) in those with the high-producing genotypes of IL-6 -174 GG and TNF-a -308 GA compared with those with lowproducing alleles. In contrast, men with high-producing LT-a +252 AA and IL-1b -511 CT&TT genotypes displayed halved 3-year survival (P < 0.05) compared with those with low-producing genotypes, whereas possession of the high-producing IL-10 -1082 GG genotype favoured survival. Serum IL-10 was higher in the high-producing IL-10 genotype in females.Conclusion. As high-producing IL-6 -174 genotype favoured 3-year survival in women, whereas the likewise high-producing LT-a +252 and IL-1b -511 genotypes were associated with poor survival in men, we conclude that the specific genotypes, in association with gender, may act as determinants for survival in elderly patients.

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Section: Methodsmentioning

confidence: 99%

Polymorphisms in cytokine genes influence long‐term survival differently in elderly male and female patients

Cederholm

Persson

Andersson

et al. 2007

Journal of Internal Medicine

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“…It is also evident that gene polymorphisms influence the expression of both pro-and anti-inflammatory cytokines. 110,111 Potential approaches to restoration of normal inflammatory response in critical care settings include anticytokines, activated protein C, intensive insulin therapy, stress doses of corticosteroids, and early goaldirected therapy in treatment of sepsis and septic shock. 110 -113 Although anti-TNF has exciting clinical applications in Crohn's disease, rheumatoid arthritis, and other rheumatic diseases, 114 -116 anti-TNF strategies have had only limited utility in patients with sepsis.…”

Section: Interventionsmentioning

confidence: 99%

Inflammation as the Key Interface of the Medical and Nutrition Universes: A Provocative Examination of the Future of Clinical Nutrition and Medicine

Jensen

2006

J Parenter Enteral Nutr

118

114

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There has been tremendous interest in inflammation by researchers, the medical community, and the lay public. Modulation of injury response is felt to represent a tenuous balance of pro- and anti-inflammatory cytokines. Adverse outcomes may result from severe, sustained, or repeated bouts of inflammation. A critical observation is that nutrition support alone is inadequate to prevent muscle loss during active inflammation. It is necessary to take inflammation into consideration in conducting appropriate nutrition assessment, intervention, and monitoring. A host of medical conditions are actually inflammatory states that have important implications for nutrition care. Multifaceted interventions that may include anti-inflammatory diets, glycemic control, physical activity, appetite stimulants, anabolic agents, anti-inflammatory agents, anticytokines, and probiotics, will be necessary to blunt undesirable aspects of inflammatory response to preserve body cell mass and vital organ functions. Nutrition practitioners can seize this opportunity to be a part of the future medical team that brings highly individualized patient care to the bedside.

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“…That is, variations in the nucleotide sequence of genes related to the influence of diets. These variations, known as single nucleotide polymorphisms (SNPs), affect characteristics of individuals such as vulnerability to some lifestyle-related diseases, nutrient requirements, and sensitivity to inadequate diet composition [1,16,17]. Although instantiating the nutritionrelated SNPs is beyond the scope of this article, it should be emphasized that DNA microarray analysis is also a powerful tool for analyzing SNPs [18,19 ].…”

Section: Various Fields Of Nutrigenomicsmentioning

confidence: 99%

A perspective on DNA microarray technology in food and nutritional science

Kato¹,

Saito²,

Kimura³

2005

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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The potency of DNA microarray technology in food and nutrition science is broadly recognized. This technique will surely continue to provide researchers and the public with valuable information on the beneficial and adverse effects of food factors. It should also be acknowledged, however, that there remain problems such as standardization of the data and sharing of the results among researchers in this field.

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Genomic interactions with disease and nutrition

Cited by 31 publications

References 54 publications

Polymorphisms in cytokine genes influence long‐term survival differently in elderly male and female patients

Polymorphisms in cytokine genes influence long‐term survival differently in elderly male and female patients

Inflammation as the Key Interface of the Medical and Nutrition Universes: A Provocative Examination of the Future of Clinical Nutrition and Medicine

A perspective on DNA microarray technology in food and nutritional science

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