Genomic imprinting and the strange case of the insulin-like growth factor II receptor

Halg, David; Graham, Chris

doi:10.1016/0092-8674(91)90256-x

Cited by 462 publications

(230 citation statements)

References 17 publications

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“…Apparently, the IGF-2r functions to degrade IGF-2 (37). Hence, there is a biochemical tug of war between IGF-2 (promoting growth) and IGF-2r (restricting growth by degrading IGF-2) in mice (23). IGF-2 and IGF-2r are also imprinted in humans, although paternal imprinting of IGF-2r is not absolute (38).…”

Section: Genomic Imprinting and Growth Factorsmentioning

confidence: 99%

Intragenomic conflict and cancer

2002

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Summary Intragenomic conflict occurs when some elements within the genome produce effects that enhance their own probability of replication or transmission at the expense of other elements within the same genome. Here it is proposed that mutations involved in intragenomic conflict are particularly likely to be co-opted by evolving lineages of cancer cells, and hence should be associated with the occurrence of cancer. We discuss several types of intragenomic conflict that are associated with various forms of cancer. ª

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Section: Genomic Imprinting and Growth Factorsmentioning

confidence: 99%

Intragenomic conflict and cancer

2002

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“…The presence, in opposite parental sexes, of this unusual property in two genetically unlinked but functionally coupled genes may be related to opposing e ects of Igf2 and Igf2r expression on fetal growth (Haig and Graham, 1991). It is known that the mitogenic actions of IGF-II are transmitted by the type I IGF receptor (Kiess et al, 1987;Ellis et al, 1996), which binds both IGF-I and IGF-II and acts as a ligand-activated tyrosine kinase.…”

Section: Introductionmentioning

confidence: 99%

Aberrant imprinting of the insulin-like growth factor II receptor gene in Wilms' tumor

Grundy²,

Polychronakos

1997

Oncogene

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“…The phenomenon of genomic imprinting allows gene expression to be dependent on the parent's sex. Haig (1992) realized that ␣ = 0.5 then defines the constrained mother's interests, and ␣ = 0 those of the unconstrained father; this has some remarkable implications (Haig & Graham 1991;Haig & Westoby 1991). For example, in eutherian mammals the paternal genome appears to be particularly active in the development of the extraembryonic membranes, possibly at the expense of the mother.…”

Section: (Ii) Interbrood Competitionmentioning

confidence: 99%

Intrafamilial conflict and parental investment: a synthesis

Parker

Royle

Hartley

2002

Phil. Trans. R. Soc. Lond. B

303

296

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We outline and develop current theory on how inherent genetic conflicts of interest between the various family members can affect the flow of parental investment from parents to offspring, and discuss the problems for empirical testing that this generates. The parental investment pattern realized in nature reflects the simultaneous resolution of all the conflicts between the family players. This depends on the genetic mechanism, the mating system and reproductive constraints, on whether extra demand by progeny affects current or future sibs, and particularly on the behavioural mechanisms underlying demand (begging or solicitation) and supply (provision of parental investment by parents). The direction of deviation from the optimal parental investment for the parent(s) depends on the slope of what we term the 'effect of supply on demand', the mechanism that determines how changes in food supply affect begging levels. If increasing food increases begging (positive slope), less parental investment is supplied than the parental optimum and if increasing food decreases begging (negative slope), more parental investment is supplied. The magnitude of deviation depends on both the 'effect of supply on demand' and on the 'effect of demand on supply' (the mechanism determining how changes in begging affect food supply, which always has a positive slope). We conclude that it will often be impossible to deduce the extent of underlying conflict by establishing the amount of parental investment given relative to the ideal optimum for the parent. Some possible directions for future research are discussed.

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Genomic imprinting and the strange case of the insulin-like growth factor II receptor

Cited by 462 publications

References 17 publications

Intragenomic conflict and cancer

Intragenomic conflict and cancer

Aberrant imprinting of the insulin-like growth factor II receptor gene in Wilms' tumor

Intrafamilial conflict and parental investment: a synthesis

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