Genomic features of humoral immunity support tolerance model in Egyptian rousette bats

Larson, Peter A.; Bartlett, Maggie; Garcia, Karla; Chitty, Joseph A; Balkema‐Buschmann, Anne; Towner, Jonathan S.; Kugelman, Jeffrey R.; Palacios, Gustavo; Sánchez-Lockhart, Mariano

doi:10.1016/j.celrep.2021.109140

Cited by 24 publications

(38 citation statements)

References 111 publications

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“…However, the IGH locus is not annotated in the current ERB reference genome, thus hampering the annotation of B cell subsets with confidence. Future studies could refine ERB B cell identities, as the IGH locus is further characterized (Larson et al, 2021) and adequate tools to determine immunoglobulin secretion and function are established. Besides the general enrichment in B cells for juveniles, we found a particular interest for the VPREB3-expressing B cell cluster as it seems to be almost absent in adult specimens.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding inflammatory responses, substantial differences in innate immunity have been reported. Bats detect and respond to RNA viruses, while DNA sensing is dampened, due to limited signaling via stimulator of interferon genes (STING) (Xie et al, 2018), absence of members of the pyrin and hematopoietic interferon-inducible nuclear (HIN) domain (PYHIN) (Zhang et al, 2013) gene family, and short pentraxins (Larson et al, 2021). Interestingly, interferon (IFN) expression is constitutive in steady state in several bat species (Bondet et al, 2021;Zhou et al, 2016b).…”

Section: Introductionmentioning

confidence: 99%

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Landscape and age dynamics of immune cells in the Egyptian rousette bat

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Landscape and age dynamics of immune cells in the Egyptian rousette bat

et al. 2022

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“…Furthermore, the remaining Jk in cattle and sheep has a noncanonical RSS (59) that may favor immediate KDE-mediated ablation because initial functional rearrangement is inefficient or impossible. This could lead to the elimination of almost all IgLk rearrangements and be only the final step before the evolutionary loss of all IgLk usage, as occurred in bats (60,61).…”

Section: The Role Of Kde Igl Isotypic Exclusion and Distribution Of I...mentioning

confidence: 99%

“…If species can rely on one type of IgL, the second may gradually goes unused or be eliminated. This is the case in birds, which have been able to do so probably because they use gene conversion (42)(43)(44), but also in bats, which have expanded the Vl and V H repertoire (60). These are two known species that have eliminated IgLk (Table 1).…”

Section: Iglk To Igll Ratio In Different Speciesmentioning

confidence: 99%

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Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species

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Studies in humans and mice indicate the critical role of the surrogate light chain in the selection of the productive immunoglobulin repertoire during B cell development. However, subsequent studies using mutant mice have also demonstrated that alternative pathways are allowed. Our recent investigation has shown that some species, such as pig, physiologically use preferential rearrangement of authentic light chains, and become independent of surrogate light chains. Here we summarize the findings from swine and compare them with results in other species. In both groups, allelic and isotypic exclusions remain intact, so the different processes do not alter the paradigm of B-cell monospecificity. Both groups also retained some other essential processes, such as segregated and sequential rearrangement of heavy and light chain loci, preferential rearrangement of light chain kappa before lambda, and functional κ-deleting element recombination. On the other hand, the respective order of heavy and light chains rearrangement may vary, and rearrangement of the light chain kappa and lambda on different chromosomes may occur independently. Studies have also confirmed that the surrogate light chain is not required for the selection of the productive repertoire of heavy chains and can be substituted by authentic light chains. These findings are important for understanding evolutional approaches, redundancy and efficiency of B-cell generation, dependencies on other regulatory factors, and strategies for constructing therapeutic antibodies in unrelated species. The results may also be important for explaining interspecies differences in the proportional use of light chains and for the understanding of divergences in rearrangement processes. Therefore, the division into two groups may not be definitive and there may be more groups of intermediate species.

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Different species of Chiroptera: Immune cells and molecules

Liu,

Wang

et al. 2024

Journal of Medical Virology

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The distinct composition and immune response characteristics of bats’ innate and adaptive immune systems, which enable them to serve as host of numerous serious zoonotic viruses without falling ill, differ substantially from those of other mammals, it have garnered significant attention. In this article, we offer a systematic review of the names, attributes, and functions of innate and adaptive immune cells & molecules across different bat species. This includes descriptions of the differences shown by research between 71 bat species in 10 families, as well as comparisons between bats and other mammals. Studies of the immune cells & molecules of different bat species are necessary to understand the unique antiviral immunity of bats. By providing comprehensive information on these unique immune responses, it is hoped that new insights will be provided for the study of co‐evolutionary dynamics between viruses and the bat immune system, as well as human antiviral immunity.

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Genomic features of humoral immunity support tolerance model in Egyptian rousette bats

Cited by 24 publications

References 111 publications

Landscape and age dynamics of immune cells in the Egyptian rousette bat

Landscape and age dynamics of immune cells in the Egyptian rousette bat

Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species

Different species of Chiroptera: Immune cells and molecules

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