Genomic evidence for dysregulated glutamine metabolism in the asthmatic airway epithelium

Bravo‐Solarte, Daniela C.; Stelzig, K.; Cuervo‐Pardo, Lyda; Berdnikovs, Sergejs; Chiarella, Sergio E.

doi:10.1002/clt2.12178

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…Recently, Bravo-Solarte et al, using bronchial brush samples, described genomic evidence of misregulated glutamine metabolism in airway epithelial cells from asthma patients [86]. Based on a secondary analysis of two openaccess microarray datasets from asthmatics and healthy controls, the authors found upregulation of enzymes involved in the glutamine metabolism including glutamic-oxaloacetic transaminase 1, glutamic-oxaloacetic transaminase 2, nitric oxide synthase 2, glutathione peroxidase 7, phosphoserine aminotransferase 1, pyrroline-5-carboxylate reductase 1, sirtuin 7, solute carrier family 7 member 11, and solute carrier family 39 member 8 [86].…”

Section: Asthmamentioning

confidence: 99%

Immune Metabolism in TH2 Responses: New Opportunities to Improve Allergy Treatment — Disease-Specific Findings (Part 1)

Goretzki

Zimmermann

Rainer

et al. 2022

Curr Allergy Asthma Rep

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Purpose of Review Recent high-level publications have shown an intricate connection between immune effector function and the metabolic state of the respective cells. In the last years, studies have begun analyzing the metabolic changes associated with allergies. As the first part of a two-article series, this review will briefly summarize the basics of immune metabolism and then focus on the recently published studies on metabolic changes observed in allergic patients. Recent Findings In the last 3 years, immune-metabolic research in allergology had a clear focus on asthma with some studies also reporting findings in food allergy and atopic dermatitis. Current results suggest asthma to be associated with a shift in cellular metabolism towards increased aerobic glycolysis (Warburg metabolism), while also displaying substantial changes in fatty acid- and amino acid metabolism (depending on investigated patient collective, asthma phenotype, and disease severity). Summary Understanding immune-metabolic changes in allergies will allow us to (I) better understand allergic disease pathology and (II) modulate immune-metabolic pathways to improve allergy treatment.

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Section: Asthmamentioning

confidence: 99%

Immune Metabolism in TH2 Responses: New Opportunities to Improve Allergy Treatment — Disease-Specific Findings (Part 1)

Goretzki

Zimmermann

Rainer

et al. 2022

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

show abstract

Genomic evidence for dysregulated glutamine metabolism in the asthmatic airway epithelium

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 1 publication

References 9 publications

Immune Metabolism in TH2 Responses: New Opportunities to Improve Allergy Treatment — Disease-Specific Findings (Part 1)

Immune Metabolism in TH2 Responses: New Opportunities to Improve Allergy Treatment — Disease-Specific Findings (Part 1)

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