Genomic Diversity of <i>Burkholderia pseudomallei</i> Isolates, Colombia

Duarte, Carolina; Montúfar, Franco; Moreno, Jaime; Sánchez, Dora; Rodríguez, José Yesid; Torres, Alfredo G.; Morales, Soraya; Bautista, Adriana; Huertas, Mónica Gabriela; Myers, Julia N.; Gulvik, Christopher A.; Elrod, Mindy G.; Blaney, David D.; Gee, Jay E.

doi:10.3201/eid2702.202824

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…Regarding the study area, the primarily selected studies were retrieved in databases from 12 countries in the endemic area of Asia (28/40, 70.0%), in which 14 studies (35.0%) were found in Southeast Asia [8,12,[20][21][22][23][24][25][26][27][28][29][30][31], and seven studies (17.5%) were found in South Asia [19,[32][33][34][35][36][37] and East Asia [38][39][40][41][42][43][44]. Nine studies were conducted in Australia (22.5%) [45][46][47][48][49][50][51][52][53], and three studies were performed in North, South, and Central America (7.5%) [54][55][56] (Figure -2). Regarding B. pseudomallei obtained from animal studies conducted in Australia and Southeast Asia involving species such as horses, pigs, cats, iguanas, parrots, and goats.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

A systematic review and meta-analysis of the global prevalence and relationships among Burkholderia pseudomallei sequence types isolated from humans, animals, and the environment

Laklaeng,

Phu,

Songsri

et al. 2024

Vet World

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Background and Aim: Burkholderia pseudomallei, a highly pathogenic bacterium responsible for melioidosis, exhibits ecological ubiquity and thrives within soil and water reservoirs, posing significant infection risks to humans and animals through direct contact. The aim of this study was to elucidate the genetic diversity and prevalence patterns of B. pseudomallei sequence types (STs) across a global spectrum and to understand the relationships between strains isolated from different sources. Materials and Methods: We performed a systematic review and meta-analysis in this study. Extensive research was carried out across three comprehensive databases, including PubMed, Scopus, and ScienceDirect with data collected from 1924 to 2023. Results: A total of 40 carefully selected articles contributed 2737 B. pseudomallei isolates attributed to 729 distinct STs and were incorporated into the systematic review. Among these, ST46 emerged as the most prominent, featuring in 35% of the articles and demonstrating a dominant prevalence, particularly within Southeast Asia. Moreover, ST51 consistently appeared across human, animal, and environmental studies. Subsequently, we performed a meta-analysis, focusing on nine specific STs: ST46, ST51, ST54, ST70, ST84, ST109, ST289, ST325, and ST376. Surprisingly, no statistically significant differences in their pooled prevalence proportions were observed across these compartments for ST46, ST70, ST289, ST325, and ST376 (all p > 0.69). Conversely, the remaining STs, including ST51, ST54, ST84, and ST109, displayed notable variations in their prevalence among the three domains (all p < 0.04). Notably, the pooled prevalence of ST51 in animals and environmental samples surpassed that found in human isolates (p < 0.01). Conclusion: To the best of our knowledge, this study is the first systematic review and meta-analysis to investigate the intricate relationships between STs and their sources and contributes significantly to our understanding of B. pseudomallei diversity within the One Health framework. Keywords: Burkholderia pseudomallei, melioidosis, meta-analysis, One Health, sequence type, systematic review.

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Section: Characteristics Of Included Studiesmentioning

confidence: 99%

A systematic review and meta-analysis of the global prevalence and relationships among Burkholderia pseudomallei sequence types isolated from humans, animals, and the environment

Laklaeng,

Phu,

Songsri

et al. 2024

Vet World

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“…Analysis of B. pseudomallei genomes from the state of Ceara in northeast Brazil has shown the complexities of such analyses, with surprising genetic diversity but isolates still falling within a distinct subclade of Western Hemisphere B. pseudomallei [25]. Similarly diverse genotypes have been described from Colombia [26]. A notable finding in Brazil is a relatively high proportion of cases of melioidosis occurring in children, with severe disease and high mortality [27 ▪ ].…”

Section: Epidemiologymentioning

confidence: 99%

Melioidosis and Burkholderia pseudomallei: progress in epidemiology, diagnosis, treatment and vaccination

Currie

2022

Current Opinion in Infectious Diseases

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Purpose of reviewMelioidosis and its causative bacterium Burkholderia pseudomallei are being found in unexpected locations and bacterial genotyping is providing new insights into global spread and where and how individuals are being infected. This review summarizes recent studies covering the epidemiology, diagnosis, treatment, and prevention of melioidosis. Recent findingsWhole-genome sequencing of B. pseudomallei from patients and environmental sampling is informing the phylogeography of B. pseudomallei at regional, continental, and global levels, while also defining the epidemiology for individual cases. The situation in Africa remains the most unresolved, while the evolving story of B. pseudomallei in the Americas may establish that B. pseudomallei is endemic in parts of southern USA. Guidelines for diagnosis and treatment of melioidosis are well established, and published mortality has decreased from 50% or higher to 10% or lower in some countries but access to laboratory and therapeutic resources are not available or are extremely limited in many melioidosis-endemic regions.

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“…There have been considerable advances in recent years in mapping the presence of B. pseudomallei and the magnitude of melioidosis in India, 26 Sri Lanka, 27 Africa, 28 and South America. 29 , 30 Environmental sampling established that B. pseudomallei is ecologically established and widely dispersed in the environment in Puerto Rico. 31 …”

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confidence: 99%