Genomic Diversity and Recombination Analysis of the Spike Protein Gene from Selected Human Coronaviruses
Sayed Sartaj Sohrab,
Fatima Alsaqaf,
Ahmed Mohamed Hassan
et al.
Abstract:Human coronaviruses (HCoVs) are seriously associated with respiratory diseases in humans and animals. The first human pathogenic SARS-CoV emerged in 2002–2003. The second was MERS-CoV, reported from Jeddah, the Kingdom of Saudi Arabia, in 2012, and the third one was SARS-CoV-2, identified from Wuhan City, China, in late December 2019. The HCoV-Spike (S) gene has the highest mutation/insertion/deletion rate and has been the most utilized target for vaccine/antiviral development. In this manuscript, we discuss t… Show more
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