Genomic disparity impacts variant classification of cancer susceptibility genes in Turkish breast cancer patients
Nihat B. Agaoglu,
Busra Unal,
Connor P. Hayes
et al.
Abstract:ObjectiveTurkish genome is underrepresented in large genomic databases. This study aims to evaluate the effect of allele frequency in the Turkish population in determining the clinical utility of germline findings in breast cancer, including invasive lobular carcinoma (ILC), mixed invasive ductal and lobular carcinoma (IDC‐L), and ductal carcinoma (DC).MethodsTwo clinic‐based cohorts from the Umraniye Research and Training Hospital (URTH) were used in this study: a cohort consisting of 132 women with breast ca… Show more
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