Genomic Deletion of PFKFB3 Decreases In Vivo Tumorigenesis
Yoannis Imbert-Fernandez,
Simone M. Chang,
Lilibeth Lanceta
et al.
Abstract:Rapidly proliferative processes in mammalian tissues including tumorigenesis and embryogenesis rely on the glycolytic pathway for energy and biosynthetic precursors. The enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) plays an important regulatory role in glycolysis by activating the key rate-limiting glycolytic enzyme, 6-phosphofructo-1-kinase (PFK-1). We have previously determined that decreased PFKFB3 expression reduced glycolysis and growth in transformed cells in vitro and suppresse… Show more
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