2015
DOI: 10.1016/j.eururo.2015.07.039
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Genomic Characterization of Upper Tract Urothelial Carcinoma

Abstract: Background Despite a similar histologic appearance, upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB) tumors have distinct epidemiologic and clinicopathologic differences. Objective To investigate whether the differences between UTUC and UCB result from intrinsic biological diversity. Design, setting, and participants Tumor and germline DNA from patients with UTUC (n = 83) and UCB (n = 102) were analyzed using a custom next-generation sequencing assay to identify somatic… Show more

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Cited by 211 publications
(216 citation statements)
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References 28 publications
(30 reference statements)
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“…Targeted capture-based next-generation sequencing (Memorial Sloan Kettering Integrated Mutation Profiling of Actionable Cancer Targets, MSK-IMPACT) to identify somatic mutations and copy number alterations was performed on all specimens (10, 11). Pre-specified genomic alterations deemed to have functional significance were analyzed.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Targeted capture-based next-generation sequencing (Memorial Sloan Kettering Integrated Mutation Profiling of Actionable Cancer Targets, MSK-IMPACT) to identify somatic mutations and copy number alterations was performed on all specimens (10, 11). Pre-specified genomic alterations deemed to have functional significance were analyzed.…”
Section: Methodsmentioning
confidence: 99%
“…The genomic landscape of UTUC is less clear. Recently, our group published a comparative genomic analysis of UTUC and bladder UC (10). This work demonstrates that the types of mutations found in invasive bladder and upper tract tumors are similar, but the mutational frequency is quite different.…”
Section: Introductionmentioning
confidence: 99%
“…Intraluminal tumor seeding seems like the most possible reason for IVR after URS because Chen et al [29] found that clipping the distal ureter prior to RNU could significantly reduce IVR. However, studies have demonstrated that the UC that occurred in upper tract and bladder had similar genomic characterisation using next-generation sequencing, thus it is much harder to distinguish whether the origin of subsequent IVR was from seeds of UTUC [30]. Regardless, it is now clear that preoperative URS increases the risk of IVR after RNU.…”
Section: Discussionmentioning
confidence: 99%
“…In this month's issue of European Urology, Sfakianos and colleagues [4] report on the largest targeted next-generation DNA-sequencing study of UTUC. The authors used an exoncapture assay consisting of 300 cancer-associated genes (Memorial Sloan Kettering Cancer Center's IMPACT platform) to compare somatic DNA mutations in a cohort of 59 highgrade UTUCs versus 102 high-grade urothelial cancers of the bladder (UCBs) and in 23 low-grade versus 59 high-grade UTUCs, using either frozen or paraffin-embedded tissues from nephroureterectomy.…”
mentioning
confidence: 97%