Genomic characterization and transcription analysis of European sea bass (Dicentrarchus labrax) rtp3 genes

Moreno, Patricia; Gemez-Mata, Juan; Alvarez-Torres, Daniel; Garcia-Rosado, Esther; Bejar, Julia; Alonso, M. Carmen

doi:10.1016/j.molimm.2023.10.009

Cited by 1 publication

(1 citation statement)

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“…In addition, PCA has demonstrated a strong correlation between irf3 and rtp3 transcription (r = 0.875, p < 0.001). In this regard, a recent study has demonstrated rtp3 induction in sea bass following poly I:C inoculation, indicating that rtp3 can be considered as an IFN-stimulated gene (ISG) [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Immune Gene Transcription in Sea Bream (Sparus aurata) Challenged with RGNNV or RGNNV/SJNNV Betanodaviruses

Gemez-Mata,

Moreno,

Alvarez-Torres

et al. 2024

Pathogens

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Gilthead sea bream and European sea bass display different resistance–susceptibility patterns during infection with different nervous necrosis virus (NNV) species, which may derive from differences in the triggered immune response. Based on this premise, we analysed the transcription of several selected immune-related genes in sea bream experimentally infected with NNV isolates obtained from sea bass (DlNNV, RGNNV) or sea bream (SaNNV, RGNNV/SJNNV). Viral replication only occurred in SaNNV-inoculated fish; therefore, the differences between the immune response elicited by both viruses may be the key to understanding the mechanism behind the inhibition of DlNNV replication. Principal component analysis clustered samples according to the viral isolate from 1 day post infection onwards and evidenced differences in the immune response against both viruses, even though no mortalities or symptoms were recorded. The response against DlNNV is characterized by higher rtp3 transcription early after the infection, longer-lasting il-10 transcription and stronger induction of casp1 and hsp70. These genes should be targets for future studies in order to elucidate their role in hampering NNV replication in sea bream, which is essential for developing effective prophylactic measures.

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Section: Discussionmentioning

confidence: 99%