Genomic Catastrophe and Neoplastic Transformation

Coleman, William B.

doi:10.1016/j.ajpath.2015.05.001

Cited by 1 publication

(1 citation statement)

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“…The regulation of cell growth and proliferation is controlled by interactions of proteins that take part in antiproliferative functions such as tumor suppressors. Dysregulation of cell growth and proliferation transforms non-neoplastic cells into a tumorigenic state resulting from multiple genetic alterations ( 1 ). Cell cycle progression, differentiation, and apoptosis are all regulated by the B cell translocation gene (BTG)/TOB family of antiproliferation proteins.…”

Section: Introductionmentioning

confidence: 99%

Emerging role of anti-proliferative protein BTG1 and BTG2

Kim

Jung

Hwang

2022

BMB Rep

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The B cell translocation gene 1 (BTG1) and BTG2 play a key role in a wide range of cellular activities including proliferation, apoptosis, and cell growth via modulating a variety of central biological steps such as transcription, post-transcriptional, and translation. BTG1 and BTG2 have been identified by genomic profiling of B-cell leukemia and diverse lymphoma types where both genes are commonly mutated, implying that they serve as tumor suppressors. Furthermore, a low expression level of BTG1 or BTG2 in solid tumors is frequently associated with malignant progression and poor treatment outcomes. As physiological aspects, BTG1 and BTG2 have been discovered to play a critical function in regulating quiescence in hematopoietic lineage such as Hematopoietic stem cells (HSCs) and naïve and memory T cells, highlighting their novel role in maintaining the quiescent state. Taken together, emerging evidence from the recent studies suggests that BTG1 and BTG2 play a central antiproliferative role in various tissues and cells, indicating their potential as targets for innovative therapeutics.

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Section: Introductionmentioning

confidence: 99%