Genomic breakpoints and clinical features of MLL-TET1 rearrangement in acute leukemias

5-Hydroxymethylcytosine: An epigenetic mark frequently deregulated in cancer

“…This translocation does not occur very frequently with only 13 cases reported in the literature to date: 11 AML and 2 ALL patients [66]. 5hmC measurements have not yet been reported in these patients.…”

MLL-TET1 fusion protein promotes immortalization of myeloid progenitor cells and leukemia development

“…myeloid lineages. [8][9][10] We induced the myeloid progenitor cells by growing murine bone marrow mononuclear cells with Iscove modified Dulbecco medium containing 15% fetal bovine serum, interleukin-3, interleukin-6 and stem cell factor for 48 h. During this period, mononuclear cells were activated into myeloid progenitor cells and the number of myeloid progenitor cells was increased. The breakpoint region of the MT1 fusion between exon 9 of MLL and exon 9 of TET1 has been previously identified ( Figure 1A).…”

First description of the t(10;11)(q22;q23)/MLL-TET1 translocation in a T-cell lymphoblastic lymphoma, with subsequent lineage switch to acute myelomonocytic myeloid leukemia

“…1 So far, 13 cases have been reported in the literature, 11 in acute myeloid leukemia (AML) patients [1][2][3][4][5][6][7][8] and 2 in B-cell precursor acute lymphoblastic leukemia (ALL). 9 It was also recently reported that MLL is fused to TET1 in only 5 out of 1,590 MLL rearranged AML cases (0.3%).…”

“…This translocation was found as the sole chromosomal abnormality in blast cells (Figure 2), as frequently observed (4 of 10 cases with available karyotype reported by Lee et al). 1 …”

“…As proposed by Lee et al, we confirm the need to collect and report more cases and to test the leukemogenic activity of MLL-TET1 associated to demethylating agents in a murine bone marrow transduction/transplantation model system. Antoine Ittel, 1,2,3 Eric Jeandidier, 3,4 Catherine Helias, 1,3 Nathalie Perrusson, 2 Catherine Humbrecht, 4 Bruno Lioure, 5 Isabelle Mazurier, 6 Caroline Mayeur-Rousse, 1 Amandine Lavaux, 3,4 Sylvie Thiebault, 8 Felix Lerintiu, 9 Carine Gervais, 1,3 …”