Genomic and phylogenomic analysis of Fusobacteriaceae family and proposal to reclassify Fusobacterium naviforme Jungano 1909 into a novel genus as Zandiella naviformis gen. nov., comb. nov. and reclassification of Fusobacterium necrophorum subsp. funduliforme as later heterotypic synonym of Fusobacterium necrophorum subsp. necrophorum and Fusobacterium equinum as later heterotypic synonym of Fusobacterium gonidiaformans

Fatahi-Bafghi, Mehdi

doi:10.1007/s10482-023-01921-1

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2024

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Cited by 2 publications

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Notification of changes in taxonomic opinion previously published outside the IJSEM. List of changes in taxonomic opinion no. 40

Oren,

Göker

2024

International Journal of Systematic and Evolutionary Microbiology

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Notification of changes in taxonomic opinion previously published outside the IJSEM. List of changes in taxonomic opinion no. 40

Oren,

Göker

2024

International Journal of Systematic and Evolutionary Microbiology

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Tangled genetic relationships within theFusobacteriumgenus

Molteni,

Forni,

Cagliani

et al. 2024

Preprint

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Fusobacteria have been associated to different diseases, including colorectal cancer (CRC), but knowledge of which taxonomic groups contribute to specific conditions is incomplete. We analyzed the genetic diversity and relationships within the Fusobacterium genus. We report recent and ancestral recombination in core genes, indicating that fusobacteria have mosaic genomes and emphasizing that taxonomic demarcation should not rely on single genes/gene regions. Across databases, we found ample evidence of species miss-classification and of undescribed species, which are both expected to complicate disease association. By focusing on a lineage that includes F. periodonticum/pseudoperiodonticum and F. nucleatum, we show that genomes belong to four modern populations, but most known species/subspecies emerged from individual ancestral populations. Of these, the F. periodonticum/pseudoperiodonticum population experienced the lowest drift and displays the highest genetic diversity, in line with the less specialized distribution of these bacteria in oral sites. A highly drifted ancestral population instead contributed genetic ancestry to a new species, which includes genomes classified within the F. nucleatum animalis diversity in a recent CRC study. Thus, evidence herein calls for a re-analysis of F. nucleatum animalis features associated to CRC. More generally, our data inform future molecular profiling approaches to investigate the epidemiology of Fusobacterium-associated diseases.

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Cited by 2 publications

References 57 publications

Notification of changes in taxonomic opinion previously published outside the IJSEM. List of changes in taxonomic opinion no. 40

Notification of changes in taxonomic opinion previously published outside the IJSEM. List of changes in taxonomic opinion no. 40

Tangled genetic relationships within theFusobacteriumgenus

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