Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood
Yasminka A. Jakubek,
Xiaolong Ma,
Adrienne M. Stilp
et al.
Abstract:Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence of mLOY is associated with altered blood cell counts and increased risk of Alzheimer's disease, solid tumors, and other age-related diseases. We sought to gain a better understanding of genetic drivers and associated phenotypes of mLOY through analyses of whole genome sequencing of a large set of genetically diverse males from the Trans-Omics for Precision Medicine (TOPMed) program. This approach ena… Show more
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