Genomic and Metabolite Profiling Reveal a Novel Streptomyces Strain, QHH-9511, from the Qinghai-Tibet Plateau

Abstract

Undescribed microorganisms from special habitats are being screened for anti-superbug drug molecules. In a project to screen actinomycetes for anti-MRSA activity, we isolated a Streptomyces strain from Qinghai Lake lichens.

Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034

“…Actinomycetes have been one of the main sources of bioactive compounds used in medicine. With the fast development of sequencing and genomics, it has been observed that strains known for the production of one or a few molecules have the potential to produce many more unknown metabolites [10,11,19,20]. The Streptomyces species are a source of important antitumor compounds such as actinomycin, mitomycin, anthracycline, or bleomycin.…”

“…Unfortunately, in recent decades, the rate of rediscovery of already-described molecules has frustrated many research efforts [21]. In order to find novel molecular structures, several different strategies are being followed, from manipulating the genome to forcing the expression of cryptic clusters (genome mining) [22] or looking for new strains in barely explored environments such as the Earth's poles, insect teguments, high altitudes, caves or marine sources [20,[23][24][25][26][27]. Several different cytotoxic compounds have been recently isolated from Streptomyces [28][29][30][31] In this work, we isolated microorganisms from marine sediments in Indonesia.…”