Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients

Yelin, Idan; Flett, Kelly B.; Merakou, Christina; Mehrotra, Preeti; Stam, Jason; Snesrud, Erik; Hinkle, Mary; Lesho, Emil; McGann, Patrick; McAdam, Alexander J.; Sandora, Thomas J.; Kishony, Roy; Priebe, Gregory P.

doi:10.1038/s41591-019-0626-9

Cited by 200 publications

(170 citation statements)

References 39 publications

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“…Although the long term effects of A. muciniphila supplementation are unknown with concerns over the translocation of probiotics (76), this bacterium may play a crucial role in increasing the efficacy of metabolic and cancer therapies and provide strong scientific rationale to launch microbiota-based clinical trials.…”

Section: Supplementation Of a Muciniphila In The Context Of Metabolimentioning

confidence: 99%

The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation

et al. 2020

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Section: Supplementation Of a Muciniphila In The Context Of Metabolimentioning

confidence: 99%

The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation

et al. 2020

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“…As a wide range of species and doses of probiotics have been used in the different trials, no recommendation could be made for the dose or a particular type of probiotic, with the exception of Saccharomyces boulardii, which should not be used as it is considered unsafe in ICU patients [104]. In addition, a recent study showed that critically ill patients who were treated with probiotics had a greater risk of developing Lactobacillus bacteremia compared to non-treated patients [105]. Clearly, larger and better-designed clinical trials are needed to confirm the benefits of probiotics in sepsis before their use can be recommended in ICU patients.…”

Section: Use Of Probiotics In Sepsismentioning

confidence: 99%

The Importance of the Microbiome in Critically Ill Patients: Role of Nutrition

et al. 2019

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Critically ill patients have an alteration in the microbiome in which it becomes a disease-promoting pathobiome. It is characterized by lower bacterial diversity, loss of commensal phyla, like Firmicutes and Bacteroidetes, and a domination of pathogens belonging to the Proteobacteria phylum. Although these alterations are multicausal, many of the treatments administered to these patients, like antibiotics, play a significant role. Critically ill patients also have a hyperpermeable gut barrier and dysregulation of the inflammatory response that favor the development of the pathobiome, translocation of pathogens, and facilitate the emergence of sepsis. In order to restore the homeostasis of the microbiome, several nutritional strategies have been evaluated with the aim to improve the management of critically ill patients. Importantly, enteral nutrition has proven to be more efficient in promoting the homeostasis of the gut microbiome compared to parenteral nutrition. Several nutritional therapies, including prebiotics, probiotics, synbiotics, and fecal microbiota transplantation, are currently being used, showing variable results, possibly due to the unevenness of clinical trial conditions and the fact that the beneficial effects of probiotics are specific to particular species or even strains. Thus, it is of great importance to better understand the mechanisms by which nutrition and supplement therapies can heal the microbiome in critically ill patients in order to finally implement them in clinical practice with optimal safety and efficacy.

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“…How about long-term safety in microbiome intervention approaches such as prebiotics, probiotics and fecal-material transplantation? Recent researches have indicated that many of the interventions carry potential risks (Singh et al, 2018;Suez et al, 2018;DeFilipp et al, 2019;Yelin et al, 2019). And how do we manipulate microbiome with precision?…”

Section: Fact 5: Gut Microbiome Research Is Still At Its Infancymentioning

confidence: 99%

“…In addition, in commercial activities there are cases of promoting probiotics towards immune-deficient populations, which is potentially risky (Cohen, 2018). In fact, special population including ICU patients (Yelin et al, 2019) and hospitalized elderly (Dauby, 2017) are at risk of bacteraemia when intake probiotics, and in extreme cases, immune-deficient elderly could develop hepatapostema and bacteraemia after long-term ingestion of yogurts (Pararajasingam and Uwagwu, 2017).…”

Section: Fact 6: Chaos and Conflict Of Interest Exist In Gut Microbiomentioning

confidence: 99%

Seven facts and five initiatives for gut microbiome research

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Zhang

et al. 2020

Protein Cell

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Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients

Cited by 200 publications

References 39 publications

The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation

The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation

The Importance of the Microbiome in Critically Ill Patients: Role of Nutrition

Seven facts and five initiatives for gut microbiome research

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