Genomic and Chemical Decryption of the Bacteroidetes Phylum for Its Potential to Biosynthesize Natural Products

Brinkmann, Stephan; Kurz, Michael; Patras, Maria A.; Hartwig, Christoph; Marner, Michael; Leis, Benedikt; Billion, André; Kleiner, Yolanda; Bauer, Armin; Toti, Luigi; Pöverlein, Christoph; Hammann, Peter; Vilcinskas, Andreas; Glaeser, Jens; Spohn, Marius; Schäberle, Till F.

doi:10.1128/spectrum.02479-21

Cited by 16 publications

(15 citation statements)

References 114 publications

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“…Antipseudomonal potency of darobactins B and B9 was assessed by broth microdilution assays with only minor modifications to previous reports ( 42 – 44 ). All compounds were dissolved in water and tested in triplicate.…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial Activity of Ceftazidime-Avibactam, Ceftolozane-Tazobactam, Cefiderocol, and Novel Darobactin Analogs against Multidrug-Resistant Pseudomonas aeruginosa Isolates from Pediatric and Adolescent Cystic Fibrosis Patients

Marner

Kolberg²,

Horst

et al. 2023

Microbiol Spectr

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Antimicrobial resistance (AMR) represents an ever increasing threat to the health care system. Even recently licensed drugs are often not efficient for the treatment of infections caused by Gram-negative bacteria, like Pseudomonas aeruginosa , a causative agent of lung infections. To address this unmet medical need, innovative antibiotics, which possess a new mode of action, need to be developed. Here, the antibiogram of clinical isolates derived from cystic fibrosis patients was generated and new bicyclic heptapeptides, which inhibit the outer membrane protein BamA, exhibited strong activity, also against multidrug-resistant isolates.

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Section: Methodsmentioning

confidence: 99%

Antimicrobial Activity of Ceftazidime-Avibactam, Ceftolozane-Tazobactam, Cefiderocol, and Novel Darobactin Analogs against Multidrug-Resistant Pseudomonas aeruginosa Isolates from Pediatric and Adolescent Cystic Fibrosis Patients

Marner

Kolberg²,

Horst

et al. 2023

Microbiol Spectr

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“…Bacteroidetes occupy a major advantage in many fermentation processes. It can decompose macromolecule compounds, including polysaccharides, fats, and proteins, into small organic acids, including monosaccharides, lower alcohols and amino acids ( 44 , 45 ). In anaerobic fermentation, Proteobacteria consume volatile fatty acids, propionic acid, and butyric acid ( 46 ).…”

Section: Discussionmentioning

confidence: 99%

Enzymes and microorganisms jointly promote the fermentation of rapeseed cake

Song

Sun²,

Zhang³

et al. 2022

Front. Nutr.

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Rapeseed cake is a by-product of rapeseed oil separation. The nutritional components of rapeseed cake mainly include a variety of carbohydrates, proteins, and minerals. In order to improve the conversion rate of rapeseed cake, we studied the physicochemical properties, the structure of microbial communities, and the composition of metabolites in rapeseed cake after enzymatic fermentation. The results showed that the addition of enzymatic preparation increased microbial diversity. The relative abundance of Bacillus, Lysinibacillus, Empedobacter, Debaryomyces, Hyphopichia, and Komagataella in enzymatic fermentation was significantly higher than that in natural fermentation. Unlike natural fermentation, microbial diversity during enzymatic fermentation is specific, which improves the efficiency of fermentation. Otherwise, enzymatic fermentation promotes the conversion of macromolecular substances in rapeseed cake, which increases small metabolites, such as fatty acids, organic acids, amino acids and their derivatives. The metabolite enrichment pathway is mostly concentrated in sugar metabolism and fatty acid metabolism. In conclusion, after adding enzymatic preparation, enzymes and microorganisms jointly promote the transformation of macromolecules during the fermentation of rapeseed cake, which laid a good foundation for further utilization of rapeseed cake.

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“…The phylum Bacteroidetes is a promising, although underexplored, bioresource for natural product discovery ( 1 , 2 ). Bacteroidetes are among the most abundant bacteria within marine ecosystems ( 3 ), and their known bioactive natural products represent a remarkable diversity.…”

Section: Announcementmentioning

confidence: 99%

Draft Genome Sequence of Sinomicrobium sp. Strain PAP.21, Isolated from a Coast Sample of Papua, Indonesia

Riyanti

Zumkeller

Spohn

et al. 2023

Microbiol Resour Announc

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Genomic and Chemical Decryption of the Bacteroidetes Phylum for Its Potential to Biosynthesize Natural Products

Abstract: The development of pipelines for anti-infectives to be applied in plant, animal, and human health management are dried up. However, the resistance development against compounds in use calls for new lead structures.

Cited by 16 publications

References 114 publications

Antimicrobial Activity of Ceftazidime-Avibactam, Ceftolozane-Tazobactam, Cefiderocol, and Novel Darobactin Analogs against Multidrug-Resistant Pseudomonas aeruginosa Isolates from Pediatric and Adolescent Cystic Fibrosis Patients

Antimicrobial Activity of Ceftazidime-Avibactam, Ceftolozane-Tazobactam, Cefiderocol, and Novel Darobactin Analogs against Multidrug-Resistant Pseudomonas aeruginosa Isolates from Pediatric and Adolescent Cystic Fibrosis Patients

Enzymes and microorganisms jointly promote the fermentation of rapeseed cake

Draft Genome Sequence of Sinomicrobium sp. Strain PAP.21, Isolated from a Coast Sample of Papua, Indonesia

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