Genomic analysis of the first laboratory-mouse papillomavirus

Joh, Joongho; Jenson, A. Bennett; King, William; Proctor, Mary; Ingle, Arvind; Sundberg, John P.; Ghim, Shin-je

doi:10.1099/vir.0.026138-0

Cited by 65 publications

(65 citation statements)

References 29 publications

(36 reference statements)

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“…The species-specificity of HPVs has hindered the development of mouse models, other than transgenic mice, that can reveal clues about HPV carcinogenesis (Campo, 2002;Borzacchiello et al, 2009;Gissmann and Nieto, 2009;Eckert et al, 2000;Stelzer et al, 2010;Kanodia et al, 2010). Other than MusPV Joh et al, 2011), the only PV associated with any mouse species is MmiPV1, isolated from a zoo colony of European harvest mice (Bernard et al, 2010;Sundberg et al, 1996). Although there are at least five additional rodent PVs (MnPV1, McPV2, RnPV1, MaPV1, and EdPV1;Joh et al, 2011;Bernard et al, 2010), none has been entirely satisfactory as a model system since they were isolated from wild or exotic rodent species.…”

Section: Introductionmentioning

confidence: 95%

“…Other than MusPV Joh et al, 2011), the only PV associated with any mouse species is MmiPV1, isolated from a zoo colony of European harvest mice (Bernard et al, 2010;Sundberg et al, 1996). Although there are at least five additional rodent PVs (MnPV1, McPV2, RnPV1, MaPV1, and EdPV1;Joh et al, 2011;Bernard et al, 2010), none has been entirely satisfactory as a model system since they were isolated from wild or exotic rodent species. MusPV appears to be a satisfactory early stage laboratory mouse model that will reveal insight into cancers caused by PVs .…”

Section: Introductionmentioning

confidence: 96%

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Molecular diagnosis of a laboratory mouse papillomavirus (MusPV)

Joh

Jenson

Proctor

et al. 2012

Experimental and Molecular Pathology

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 96%

Molecular diagnosis of a laboratory mouse papillomavirus (MusPV)

Joh

Jenson

Proctor

et al. 2012

Experimental and Molecular Pathology

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“…The majority of PVs only infect epithelium and are highly host specific. The bovine papillomaviruses (BVPs) of the Deltapapillomavirus genus, however, have the ability to infect both epithe lial and mesenchymal cells of different species (Bernard et al, 2010;Joh et al, 2011;Munday et al, 2014). Lesions caused by PVs in domestic cats may be oral papillomas (Felis catus (Fca) PV1) , feline cu taneous viral plaques, Bowenoid carcinomas (FcaPV2 and FcaPV3) (Lange et al, 2009;Munday et al, 2013) and feline sarcoids.…”

Section: Introductionmentioning

confidence: 99%

Feline sarcoid in a 1-year-old domestic short-haired cat caused by bovine papillomavirus type 14 in Switzerland

Kiefer¹,

Tobler²,

Ramsauer³

et al. 2017

SAT

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A 1-year-old domestic short haired cat, living on a farm in Switzerland, was presented to the veterinarian with a 5 cm in diameter mass, bulging from her left nostril. The mass was only incompletely removed because of its unfavourable location. Histologically, the lesion consisted of an infiltrative growing spindeloid proliferation in close approximation to the epidermis and was diagnosed as a feline sarcoid tumour. The presence of Bovine Papillomavirus type 14 (BPV-14) specific DNA could be identified in the tissue by using two PCR assays. The amplified sequences of 194 and 549 base pairs (bp) were 99% and 100% identical with a virus isolated after autopsy, from a cat with feline sarcoid in the USA. The cat recovered completely after an even incomplete surgical excision and no recurrence could be observed 10 months later. SummaryA 1year old domestic short haired cat, living on a farm in Switzerland, was presented to the veterinarian with a 5 cm in diameter mass, bulging from her left nostril. The mass was only incompletely removed because of its unfavourable location. Histologically, the lesion con sisted of an infiltrative growing spindeloid proliferation in close approximation to the epidermis and was diag nosed as a feline sarcoid tumour. The presence of Bovine Papillomavirus type 14 (BPV14) specific DNA could be identified in the tissue by using two PCR assays. The amplified sequences of 194 and 549 base pairs (bp) were 99% and 100% identical with a virus isolated after aut opsy, from a cat with feline sarcoid in the USA. The cat recovered completely after an even incomplete surgical excision and no recurrence could be observed 10 months later.

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“…To determine whether a de novo-generated MusPV1 genome can induce papilloma formation, the genome was synthesized according to the published sequence (16) and was either circularized by intramolecular religation or encapsidated into L1/L2 capsids of the homologous virus MusPV1 or the heterologous virus HPV 16. The in vivo infectivities of these three preparations in immunodeficient, athymic NCr nude mice were evaluated by inoculating their muzzles, the location originally described for the spontaneous MusPV1-induced papillomas (13), and following the animals for 3 months.…”

Section: Generation Of a Synthetic Full-length Muspv1 Genome In Vitromentioning

confidence: 99%

Characterization of Mus musculus Papillomavirus 1 Infection In Situ Reveals an Unusual Pattern of Late Gene Expression and Capsid Protein Localization

Handisurya

Day

Thompson

et al. 2013

J Virol

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Full-length genomic DNA of the recently identified laboratory mouse papillomavirus 1 (MusPV1) was synthesized in vitro and was used to establish and characterize a mouse model of papillomavirus pathobiology. MusPV1 DNA, whether naked or encapsidated by MusPV1 or human papillomavirus 16 (HPV 16) capsids, efficiently induced the outgrowth of papillomas as early as 3 weeks after application to abraded skin on the muzzles and tails of athymic NCr nude mice. High concentrations of virions were extracted from homogenized papillomatous tissues and were serially passaged for >10 generations. Neutralization by L1 antisera confirmed that infectious transmission was capsid mediated. Unexpectedly, the skin of the murine back was much less susceptible to virion-induced papillomas than the muzzle or tail. Although reporter pseudovirions readily transduced the skin of the back, infection with native MusPV1 resulted in less viral genome amplification and gene expression on the back, including reduced expression of the L1 protein and very low expression of the L2 protein, results that imply skin region-specific control of postentry aspects of the viral life cycle. Unexpectedly, L1 protein on the back was predominantly cytoplasmic, while on the tail the abundant L1 was cytoplasmic in the lower epithelial layers and nuclear in the upper layers. Nuclear localization of L1 occurred only in cells that coexpressed the minor capsid protein, L2. The pattern of L1 protein staining in the infected epithelium suggests that L1 expression occurs earlier in the MusPV1 life cycle than in the life cycle of high-risk HPV and that virion assembly is regulated by a previously undescribed mechanism.

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Genomic analysis of the first laboratory-mouse papillomavirus

Cited by 65 publications

References 29 publications

Molecular diagnosis of a laboratory mouse papillomavirus (MusPV)

Molecular diagnosis of a laboratory mouse papillomavirus (MusPV)

Feline sarcoid in a 1-year-old domestic short-haired cat caused by bovine papillomavirus type 14 in Switzerland

Characterization of Mus musculus Papillomavirus 1 Infection In Situ Reveals an Unusual Pattern of Late Gene Expression and Capsid Protein Localization

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