Genomic Analysis of Abnormal DNAM Methylation in Parathyroid Tumors

Li, Qing; Li, Yonghao; Sun, Ximei; Zhang, Xinlei; Zhang, Mei

doi:10.1155/2022/4995196

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…Other studies have found that miRNAs like miR-222 [13], miR-503 [13] , and miR-517c [14] are significantly upregulated in parathyroid carcinoma. Bioinformatics has also been used to identify key genes and molecular pathways in parathyroid neoplasms [15], and thyroid cancer microarray profiles have been examined to investigate differential gene expression and pathway enrichment [16] . Mehrdad Ameri et al successfully used bioinformatics methods to screen biomarkers for follicular thyroid carcinoma (FTC) and FTA.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Common Key Genes in Differentiating Parathyroid Adenoma From Thyroid Adenoma

Lin

Mou

et al. 2023

Horm Metab Res

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Recent studies have demonstrated the close relationship between parathyroid adenoma(PA) and thyroid follicular adenoma(FTA). However, the underlying pathogenesis remains unknown. This study focused on exploring common pathogenic genes, as well as the pathogenesis of these two diseases, through bioinformatics methods. This work obtained PA and FTA datasets from the Integrated Gene Expression Database to identify the common differentially expressed genes (DEGs) of two diseases. The functions of the genes were investigated by GO and KEGG enrichment. The program CytoHubba was used to select the hub genes, while receiver operating characteristic curves were plotted to evaluate the predictive significance of the hub genes. The DGIbd database was used to identify gene-targeted drugs. This work detected a total of 77 DEGs. Enrichment analysis demonstrated that DEGs had activities of 3’,5'-cyclic AMP, and nucleotide phosphodiesterases and were associated with cell proliferation. NOS1, VWF, TGFBR2, CAV1, and MAPK1 were identified as hub genes after verification. The area under the curve of PA and FTA was > 0.7, and the hub genes participated in the Relaxin Signaling Pathway, focal adhesion, and other pathways. The construction of the mRNA-miRNA interaction network yielded 11 important miRNAs, while gene-targeting drug prediction identified four targeted drugs with possible effects. This bioinformatics study demonstrated that cell proliferation and tumor suppression, the hub genes co-occurring in PA and FTA, have important effects on the occurrence and progression of two diseases, which make them potential diagnostic biomarkers and therapeutic targets.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Common Key Genes in Differentiating Parathyroid Adenoma From Thyroid Adenoma

Lin

Mou

et al. 2023

Horm Metab Res

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New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN

Monteil,

Guérineau,

Gil-Nagel

et al. 2024

Physiological Reviews

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Cell excitability and its modulation by hormones and neurotransmitters involve the concerted action of membrane proteins, especially ion channels. Unique complements of co-expressed ion channels are exquisitely balanced against each other in different excitable cell types, establishing distinct electrical properties that are tailored for diverse physiological contributions, and dysfunction of any component may induce a disease state. A crucial parameter controlling cell excitability is the resting membrane potential (RMP) set by extra- and intra-cellular concentrations of ions, mainly Na+, K+, and Cl-, and their passive permeation across the cell membrane through leak ion channels. Indeed, dysregulation of RMP causes significant effects on cellular excitability. This review describes the molecular and physiological properties of the Na+ leak channel NALCN, which associates with its accessory subunits UNC-79, UNC-80, and NLF-1/FAM155 to conduct depolarizing background Na+ currents in various excitable cell types, especially neurons. Studies of animal models clearly demonstrate that NALCN contributes to fundamental physiological processes in the nervous system including the control of respiratory rhythm, circadian rhythm, sleep and locomotor behavior. Furthermore, dysfunction of NALCN and its subunits is associated with severe pathological states in humans. The critical involvement of NALCN in physiology is now well established, but its study has been hampered by the lack of specific drugs that can block or agonize NALCN currents in vitro and in vivo. Molecular tools and animal models are now available to accelerate our understanding of how NALCN contributes to key physiological functions, and the development of novel therapies for NALCN channelopathies.

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Genomic Analysis of Abnormal DNAM Methylation in Parathyroid Tumors

Cited by 2 publications

References 67 publications

Common Key Genes in Differentiating Parathyroid Adenoma From Thyroid Adenoma

Common Key Genes in Differentiating Parathyroid Adenoma From Thyroid Adenoma

New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN

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