Abstract:Background: Ethanol consumption during pregnancy results in a broad spectrum of damage, but the knowledge of its mechanism is lacking. Objective: The aim of this study is to determine ethanol-caused genomic alterations in placental cell lines after a repeated ethanol treatment in order to describe new genomic targets of cell damage. Methods: A model of sustained exposure to standard doses of ethanol on two in vitro human choriocarcinoma cell lines, JEG-3 and BeWo, was used. Chromosomic abnormalities and copy n… Show more
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