Genomic actions of 1,25-dihydroxyvitamin D3 on insulin receptor gene expression, insulin receptor number and insulin activity in the kidney, liver and adipose tissue of streptozotocin-induced diabetic rats

Calle, C.; Maestro, Beatríz; Garcı́a-Arencibia, Moisés

doi:10.1186/1471-2199-9-65

Cited by 91 publications

(81 citation statements)

References 51 publications

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“…The calcitriol directly activates the transcription of human Fig. 1 Comparison of the parameters in normal and type 2 diabetes subjects [35,36]. According to Ely prospective study, the baseline 25(OH)D concentration was inversely associated with glucose, IR, metabolic syndrome risk at 10 year follow up [37,38].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

et al. 2012

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Vitamin D is recognized to serve a wide range of biological functions. The presence of vitamin D receptors on different tissues explains it's diversity of actions. Reduced levels of vitamin D is associated with insulin resistance and increased diabetes risk. The study included 50 normal healthy individuals and 49 type 2 diabetes subjects. Fasting blood glucose, total cholesterol, triglycerides, HDLc, fasting insulin, parathyroid hormone, calcium, albumin and Homeostasis model for assessment of insulin resistance (HOMAIR) were measured in all the study participants. Type 2 diabetes subjects were divided into group 1 with 25 hydroxy vitamin D (25(OH)D) B20 ng/ml and group 2 with 25(OH)D [20 ng/ml. By the results of this study, the mean 25(OH)D level was low (20.09 ng/ml) in type 2 diabetes compared to controls (23.89 ng/ml) and the p value was 0.02. The estimated insulin resistance by HOMAIR was more in group 1 than in group 2 of diabetes with p value of 0.037. The Pearson's correlation-coefficient was negative for 25(OH)D and insulin in type 2 diabetes (r = -0.294), 25(OH)D was negatively correlated with HOMAIR in total subjects. Type 2 diabetes subjects had reduced levels of vitamin D than normal individuals. The insulin resistance was more in vitamin D deficiency state. Hence vitamin D has a role in glucose metabolism, deficiency can result in insulin resistance and diabetes.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

et al. 2012

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“…Vitamin D is also involved in insulin regulation [3,4]. 1,25-Dihydroxyvitamin D 3 , an active form of circulating vitamin D, binds to the vitamin D receptor on pancreas beta cells and enhances insulin receptor expression, resulting in improved insulin sensitivity [27,28]. Vitamin D deficiency has also been shown to impair insulin secretion in experimental studies [3,4].…”

Section: Discussionmentioning

confidence: 99%

Calcium, vitamin D and dairy intake in relation to type 2 diabetes risk in a Japanese cohort

et al. 2009

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Aims/hypothesis Calcium and vitamin D have been implicated in the development of type 2 diabetes, but epidemiological evidence is limited. We examined prospectively the relation of calcium and vitamin D intake to type 2 diabetes risk in a Japanese cohort. Methods Participants were 59,796 middle-aged and older men and women, who participated in the Japan Public Health Center-based Prospective Study and had no history of type 2 diabetes or other serious diseases. Dietary intake of calcium and vitamin D were estimated using a validated food frequency questionnaire. Logistic regression was used to assess the association between intake of these nutrients and self-reported newly diagnosed type 2 diabetes. Results During a 5 year follow-up, 1,114 cases of type 2 diabetes were documented. Overall, calcium intake was not associated with a significantly lower risk of type 2 diabetes; the multivariable odds ratio for the highest vs lowest quartiles was 0.93 (95% CI 0.71-1.22) in men and 0.76 (95% CI 0.56-1.03) in women. However, among participants with a higher vitamin D intake, calcium intake was inversely associated with diabetes risk; the odds ratio for the highest vs lowest intake categories was 0.62 (95% CI 0.41-0.94) in men and 0.59 (95% CI 0.38-0.91) in women. Dairy food intake was significantly associated with a lower risk of type 2 diabetes in women only. Conclusions/interpretation Calcium and vitamin D may not be independently associated with type 2 diabetes risk. Our finding suggesting a joint action of these nutrients against type 2 diabetes warrants further investigation.

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“…Sooy et al (52) showed that calbindin is an important regulator of insulin production, by regulating Ca concentration in the b-cell. Thirdly, s25(OH)D concentration was related to insulin sensitivity in a group of healthy non-diabetic adults (53) , and a recent animal study demonstrated that while 1,25(OH) 2 D treatment had no effect on insulin receptor expression in non-diabetic rats, it normalised the number of insulin receptors and improved insulin response to glucose transport in adipocytes in streptozotocin-induced diabetic rats, most probably by direct transcriptional activation of the rat insulin receptor gene (54) .…”

Section: Glucose and Insulin Metabolism And Type 2 Diabetesmentioning

confidence: 99%

Vitamin D and cardiometabolic health: a review of the evidence

Muldowney

Kiely

2010

Nutr. Res. Rev.

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The cardiometabolic syndrome (MetS) is a clustering of related metabolic abnormalities including abdominal adiposity, insulin resistance, hypertension, dyslipidaemia and increased inflammatory and thrombotic markers, which is linked to increased risk of type 2 diabetes, CVD and overall mortality. Several cross-sectional and prospective studies have shown an association between low vitamin D status, as indicated by concentrations of serum 25-hydroxyvitamin D (s25(OH)D), and increased prevalence of the MetS and individual CVD risk factors. These epidemiological observations are supported by mechanistic studies but experimental data are limited. The available data from intervention studies are largely confounded as most vitamin D supplementation trials were mainly carried out to explore the role of Ca in CVD and include Ca in the treatment arms. Inadequate consideration of seasonal effects on s25(OH)D concentrations is also a common design flaw in most studies. Further complications arise from shared risk factors such as adiposity and ageing, which predispose individuals to exhibit both a more pronounced risk profile and relatively lower s25(OH)D concentrations. In conclusion, while epidemiological associations are promising and a rationale for low vitamin D status as a potentially modifiable risk factor for CVD is supported by mechanistic data, suitable experimental data from appropriately designed trials are just beginning to emerge. As yet, this body of literature is too immature to draw firm conclusions on the role of vitamin D in CVD prevention. Carefully controlled vitamin D trials in well-described population groups using intervention doses that are titrated against target s25(OH)D concentrations could yield potentially valuable outcomes that may have a positive impact on CVD risk modification.

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Genomic actions of 1,25-dihydroxyvitamin D3 on insulin receptor gene expression, insulin receptor number and insulin activity in the kidney, liver and adipose tissue of streptozotocin-induced diabetic rats

Cited by 91 publications

References 51 publications

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

Calcium, vitamin D and dairy intake in relation to type 2 diabetes risk in a Japanese cohort

Vitamin D and cardiometabolic health: a review of the evidence

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