Genome-wide profiling of dysregulated piRNAs and their target genes implicated in oncogenicity of tongue squamous cell carcinoma

Chattopadhyay, Trisha; Gupta, Pooja; Nayak, Rojalin; Mallick, Bibekanand

doi:10.1016/j.gene.2022.146919

Cited by 11 publications

(8 citation statements)

References 82 publications

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“…small interfering RNAs (siRNAs) long ncRNAs (lncRNAs), enhancer RNAs (eRNAs), and Y RNAs, and so on. [24][25][26][27] Among these, miRNAs are single-stranded, 22 nucleotides (nt) long, endogenous ncRNAs that mediate posttranscriptional gene regulation in a sequence-specific manner. [28][29][30] Evidence shows that miRNA plays a crucial role in developing and progressing several diseases, like retinal disorders, cardiovascular diseases, neurodegenerative diseases, and cancer.…”

Section: Introductionmentioning

confidence: 99%

“…These ncRNAs comprise a diverse type of RNA species—microRNAs (miRNAs), piwi‐interacting RNA (piRNAs), and circular RNAs (circRNAs). small interfering RNAs (siRNAs) long ncRNAs (lncRNAs), enhancer RNAs (eRNAs), and Y RNAs, and so on 24–27 . Among these, miRNAs are single‐stranded, ~22 nucleotides (nt) long, endogenous ncRNAs that mediate post‐transcriptional gene regulation in a sequence‐specific manner 28–30 .…”

Section: Introductionmentioning

confidence: 99%

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miR‐203a—A multifaceted regulator modulating cancer hallmarks and therapy response

Biswal,

Lalruatfela,

Behera

et al. 2023

IUBMB Life

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MicroRNAs (miRNAs) are a class of noncoding RNAs of about 19–25 nucleotides, which serve as critical modulators of various cellular and biological processes by target gene regulation. Dysregulated expression of miRNAs modulates the pathophysiology of various human diseases, including cancer. Among miRNAs, miR‐203a is one of the most extensively researched dysregulated miRNAs in different cancers. Our review investigated the roles of miR‐203a in the hallmarks of cancer modulating different pathways through target gene regulations, chemoresistance, its crosstalk with other ncRNAs or genes in terms of ceRNAs impacting oncogenesis, and its potential applications in the diagnosis, prognosis, and chemotherapeutic responses in different cancer types. miR‐203a impacts cancer cell behavior by regulating these exclusive hallmarks‐ sustaining proliferation, cell growth, invasion and metastasis, cell death, and angiogenesis. Besides, miR‐203a is found in human circulating biofluids like plasma or serum of colorectal cancer, cervical cancer, and hepatocellular carcinoma, hinting at its potential as a biomarker. Further, miR‐203a is involved in enhancing the chemosensitivity of cisplatin, docetaxel, paclitaxel, doxorubicin, and 5‐fluorouracil in a variety of malignancies through their cognate target genes. These results suggest that miR‐203a is a crucial multifaceted miRNA that controls cancer cell proliferation, metastasis, and chemotherapy response, shedding new light on its possible application.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

miR‐203a—A multifaceted regulator modulating cancer hallmarks and therapy response

Biswal,

Lalruatfela,

Behera

et al. 2023

IUBMB Life

Self Cite

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“…P-Element induced wimpy testis interacting RNAs (piRNAs) are an emerging class of endogenous small non-coding RNAs (ncRNAs) of about 18-36 nucleotides (nts) in length, expressed in both germline and non-germline cells of many animals, such as nematodes, insects, fish, Drosophila, Aplysia, and mammals, although these were initially thought to be germline-specific. [1][2][3][4] piRNAs were first discovered in the Suppressor of Stellate repeat locus of the Drosophila melanogaster male germline in 2001 by Gvozdev and colleagues, 5 but gained their name in 2006. 6 Besides transposon silencing and maintaining genome integrity, piRNAs were recently reported in somatic cells regulating gene expression.…”

Section: Introductionmentioning

confidence: 99%

“…10 Our laboratory has also reported several piRNAs impacting various biological processes by modulating the expression of mRNAs of target genes posttranscriptionally. 1,[11][12][13][14] Other studies also report piRNAs regulating gene expression by binding to mRNAs. 15 To fully understand piRNA-mediated gene regulations and their implications in different biological phenomena, piRNA target prediction, and validation have become vital.…”

Section: Introductionmentioning

confidence: 99%

TarpiD, a database of putative and validated targets of piRNAs

et al. 2023

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“…However, in vivo and in vitro experiments have successfully used siRNAs against undruggable targets for treating cancer and other diseases [10][11][12]. Therefore, candidate genes responsible for the development of many diseases have been identified [13][14][15][16][17]. This approach allows us to specify disease causes and develop diagnosis and therapies more effectively.…”

Section: Introductionmentioning

confidence: 99%

Extraordinary Interactions of piRNAs with mRNA of Candidate Genes in Esophageal Squamous Cell Carcinoma

Ivashchenko,

Rakhmetullina,

Akimniyazova

et al. 2023

Preprint

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Recently, a database of human piRNAs has been created, which allows studying the binding of many piRNAs to mRNAs of genes involved in many diseases, including cancer. In the present work, we investigated what piRNAs can interact with candidate esophageal squamous cell carcinoma (ESCC) genes. The binding of 480 thousand piRNAs with mRNAs of 66 candidate ESCC genes was studied. Bioinformatic studies found that piRNAs bind only to the mRNAs of nine candidate genes: AURKA, BMP7, GCOM1, ERCC1, MTHFR, SASH1, SIX4, SULT1A1, and TP53. It has been shown that piRNAs can bind to mRNA by overlapping nucleotide sequences in limited 3'UTR and 5'UTR regions called clusters of binding sites (BSs). The existence of clusters of piRNA BSs significantly reduces the proportion of nucleotide sequences of these sites in the mRNA of target genes. Competition between piRNAs occurs for binding to the mRNA of target genes. Individual piRNAs and groups of piRNAs that have separate BSs and clusters of BSs in the mRNAs of two or more candidate genes have been identified in the mRNAs of these genes. This organization of piRNAs BSs indicates the interdependence of the expression of candidate genes through piRNAs. Significant differences in the ability of genes to interact with piRNAs avoid the side effects of piRNAs on genes with the lack of binding of such piRNAs. Individual piRNAs and sets of piRNAs are proposed and recommended for the diagnosis and therapy of ESCC.

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Genome-wide profiling of dysregulated piRNAs and their target genes implicated in oncogenicity of tongue squamous cell carcinoma

Cited by 11 publications

References 82 publications

miR‐203a—A multifaceted regulator modulating cancer hallmarks and therapy response

miR‐203a—A multifaceted regulator modulating cancer hallmarks and therapy response

TarpiD, a database of putative and validated targets of piRNAs

Extraordinary Interactions of piRNAs with mRNA of Candidate Genes in Esophageal Squamous Cell Carcinoma

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