Genome‐wide profiles of DNA damage represent highly accurate predictors of mammalian age
Huifen Cao,
Bolin Deng,
Tianrong Song
et al.
Abstract:The identification of novel age‐related biomarkers represents an area of intense research interest. Despite multiple studies associating DNA damage with aging, there is a glaring paucity of DNA damage‐based biomarkers of age, mainly due to the lack of precise methods for genome‐wide surveys of different types of DNA damage. Recently, we developed two techniques for genome‐wide mapping of the most prevalent types of DNA damage, single‐strand breaks and abasic sites, with nucleotide‐level resolution. Herein, we … Show more
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