Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

Lien, Wen-Hui; Guo, Xingyi; Polak, Lisa; Lawton, Lee N.; Young, Richard A.; Zheng, Deyou; Fuchs, Elaine

doi:10.1016/j.stem.2011.07.015

Cited by 187 publications

(271 citation statements)

References 44 publications

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“…Our work also supports the emerging view that epigenetic mechanisms are important for HF SC activation (30,31). Among the chromatin factors that regulate HF SC behaviors in vivo is Jarid2, a component of the polycomb repressive complex 2 (PRC2) that facilitates PRC2 recruitment to target loci and that regulates PRC2 histone H3 lysine 27 (H3K27) methyltransferase activity (31).…”

Section: Discussionsupporting

confidence: 80%

Pygo2 regulates β-catenin–induced activation of hair follicle stem/progenitor cells and skin hyperplasia

Sun

Watanabe

Fallahi

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Understanding the epigenetic mechanisms that control the activation of adult stem cells holds the promise of tissue and organ regeneration. Hair follicle stem cells have emerged as a prime model to study stem cell activation. Wnt/β-catenin signaling controls multiple aspects of skin epithelial regeneration, with its excessive activity promoting the hyperactivation of hair follicle stem/ progenitor cells and tumorigenesis. The contribution of chromatin factors in regulating Wnt/β-catenin pathway function in these processes is unknown. Here, we show that chromatin effector Pygopus homolog 2 (Pygo2) produced by the epithelial cells facilitates depilation-induced hair regeneration, as well as β-catenin-induced activation of hair follicle stem/early progenitor cells and trichofolliculoma-like skin hyperplasia. Pygo2 maximizes the expression of Wnt/β-catenin targets, but is dispensable for β-catenin-mediated expansion of LIM/homeobox protein Lhx2 + cells, in the stem/early progenitor cell compartment of the hair follicle. Moreover, β-catenin and Pygo2 converge to induce the accumulation and acetylation of tumor suppressor protein p53 upon the cell cycle entry of hair follicle early progenitor cells and in cultured keratinocytes. These findings identify Pygo2 as an important regulator of Wnt/ β-catenin function in skin epithelia and p53 activation as a prominent downstream event of β-catenin/Pygo2 action in stem cell activation.

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Section: Discussionsupporting

confidence: 80%

Pygo2 regulates β-catenin–induced activation of hair follicle stem/progenitor cells and skin hyperplasia

Sun

Watanabe

Fallahi

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…It is an active state that involves important changes in cell physiology, including energy metabolism and cell adhesion (Venezia et al 2004;Coller et al 2006;Fukada et al 2007;Pallafacchina et al 2010;Lien et al 2011;Brohl et al 2012;Valcourt et al 2012).…”

mentioning

confidence: 99%

Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence

Martynoga¹,

et al. 2013

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The majority of neural stem cells (NSCs) in the adult brain are quiescent, and this fraction increases with aging. Although signaling pathways that promote NSC quiescence have been identified, the transcriptional mechanisms involved are mostly unknown, largely due to lack of a cell culture model. In this study, we first demonstrate that NSC cultures (NS cells) exposed to BMP4 acquire cellular and transcriptional characteristics of quiescent cells. We then use epigenomic profiling to identify enhancers associated with the quiescent NS cell state. Motif enrichment analysis of these enhancers predicts a major role for the nuclear factor one (NFI) family in the gene regulatory network controlling NS cell quiescence. Interestingly, we found that the family member NFIX is robustly induced when NS cells enter quiescence. Using genome-wide location analysis and overexpression and silencing experiments, we demonstrate that NFIX has a major role in the induction of quiescence in cultured NSCs. Transcript profiling of NS cells overexpressing or silenced for Nfix and the phenotypic analysis of the hippocampus of Nfix mutant mice suggest that NFIX controls the quiescent state by regulating the interactions of NSCs with their microenvironment.

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“…XIAP −/− mice are viable and do not display overt phenotypes (7,25). However, microarray and chromatin immunoprecipitation sequencing analyses indicate that XIAP is expressed throughout skin epithelium, including the bulge (26). Because ARTS can promote ubiquitination and degradation of XIAP (27,28), we compared XIAP protein levels in wildtype and Sept4/ARTS −/− HFSCs.…”

mentioning

confidence: 99%

sept4/Arts regulates stem cell apoptosis and skin regeneration

Fuchs¹,

Brown²,

Gorenc³

et al. 2016

European Journal of Cancer

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Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

Cited by 187 publications

References 44 publications

Pygo2 regulates β-catenin–induced activation of hair follicle stem/progenitor cells and skin hyperplasia

Pygo2 regulates β-catenin–induced activation of hair follicle stem/progenitor cells and skin hyperplasia

Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence

sept4/Arts regulates stem cell apoptosis and skin regeneration

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