Genome-wide linkage analysis of inguinal hernia in pigs using affected sib pairs

Abstract

Background: Inguinal and scrotal hernias are of great concern to pig producers, and lead to poor animal welfare and severe economic loss. Selection against these conditions is highly preferable, but at this time no gene, Quantitative Trait Loci (QTL), or mode of inheritance has been identified in pigs or in any other species. Therefore, a complete genome scan was performed in order to identify genomic regions affecting inguinal and scrotal hernias in pigs. Records from seedstock breeding farms were collected. No clinical examinations were executed on the pigs and there was therefore no distinction between inguinal and scrotal hernias. The genome scan utilised affected sib pairs (ASP), and the data was analysed using both an ASP test based on Non-parametric Linkage (NPL) analysis, and a Transmission Disequilibrium Test (TDT).

Haplotype analysis of β‐actin gene for its association with sperm quality and boar fertility

“…This confirms that the haplotype analysis is more powerful than the single‐SNP analysis as previously shown both within genes (Daly & Day 2001; Stephens et al. 2001) as well as in the genomic regions (Grindflek et al. 2006).…”

WITHDRAWN: Genome-wide association analysis of inguinal/scrotal hernia in pigs using specific length amplified fragment (SLAF) sequencing

“…In total, 6 genes (CPNE5, DEGS1, PLCG2, PRKCE, NUAK1 and TENM3) were confirmed for further genotyping in 270 individuals. Furthermore, two strong candidate genes COL2A1 [27] and MMP2 [28], which were proved to be associated with increased risk of inguinal/scrotal hernias in former studies were selected for the replication study to measure the relatedness with hernias in our group. Interestingly, the results in Table 4 show that 4 of 8 SNPs were significantly (p < 0.05) associated with the inguinal/scrotal hernia in 270 pigs.…”

Primary mesh augmentation with fibrin glue for abdominal wall closure—investigations on a biomechanical model

“…Nonetheless, there is growing evidence that this problem is of a much more multifaceted nature than hitherto thought. Today, we know that myriad tissue factors, be they genetically mediated [13] or related to hypoperfusion of the tissue, are implicated (endogenous factors) [3]. Collagen metabolism changes, which are also responsible for the occurrence of primary hernias, no doubt also contribute to the genesis of incisional hernias, but these are associated with essentially more complex manifestations [3,[14][15][16].…”