Genome-wide identification of transcriptional enhancers during human placental development and association with function, differentiation, and disease
David M Owen,
Minjung Kwon,
Xuan Huang
et al.
Abstract:The placenta is a dynamic organ that must perform a remarkable variety of functions during its relatively short existence in order to support a developing fetus. These functions include nutrient delivery, gas exchange, waste removal, hormone production, and immune barrier protection. Proper placenta development and function are critical for healthy pregnancy outcomes, but the underlying genomic regulatory events that control this process remain largely unknown. We hypothesized that mapping sites of transcripti… Show more
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