2007
DOI: 10.4049/jimmunol.178.6.3648
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Genome-Wide Identification of Novel Genes Involved in Early Th1 and Th2 Cell Differentiation

Abstract: Th cell subtypes, Th1 and Th2, are involved in the pathogenesis or progression of many immune-mediated diseases, such as type 1 diabetes and asthma, respectively. Defining the molecular networks and factors that direct Th1 and Th2 cell differentiation will help to understand the pathogenic mechanisms causing these diseases. Some of the key factors regulating this differentiation have been identified, however, they alone do not explain the process in detail. To identify novel factors directing the early differe… Show more

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Cited by 79 publications
(85 citation statements)
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References 43 publications
(68 reference statements)
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“…4 As illustrated in Fig. 1B, most of these genes were elevated in the atopic responses, including several previously recognized members of the Th2 cascade (IL-4R, IL-5, IL-13, GFI-1, ITK), as well as a cohort of novel Th2-associated genes (IL-17RB, CAMK2D, CISH, DACT1, DPP4, MAL, NDFIP2, NSMCE1, PLXDC1) reported recently by us (16) and confirmed in an independent study (28).…”
Section: Identification Of the Atopy Transcriptome In Human Cd4supporting
confidence: 81%
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“…4 As illustrated in Fig. 1B, most of these genes were elevated in the atopic responses, including several previously recognized members of the Th2 cascade (IL-4R, IL-5, IL-13, GFI-1, ITK), as well as a cohort of novel Th2-associated genes (IL-17RB, CAMK2D, CISH, DACT1, DPP4, MAL, NDFIP2, NSMCE1, PLXDC1) reported recently by us (16) and confirmed in an independent study (28).…”
Section: Identification Of the Atopy Transcriptome In Human Cd4supporting
confidence: 81%
“…Of note, application of network analysis techniques to the microarray data not only confirmed the importance of the bulk of Th2-associated genes identified by more conventional analyses in previous studies (16,28), but it also added a second tier of previously unrecognized Th2-associated genes identified purely on the basis of their patterns of interconnectivity with other members of the atopy module (Table I). These novel genes encode proteins mainly involved in generic functions such as transcriptional regulation and signal transduction; however, their precise function in allergen-driven Th cell responses remains to be investigated.…”
Section: Discussionsupporting
confidence: 64%
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“…Transcriptional profiling by DNA microarray analysis also helped clarify the genes whose expression is controlled by STAT6, and the results argue that STAT6 is clearly important for regulating Th2 status (28,29). However, these studies do not address whether these genes are directly regulated by STAT6 or not.…”
mentioning
confidence: 99%