Genome-wide identification, evolution of histone lysine demethylases (KDM) genes and their expression during gonadal development in Nile tilapia

Qin, Zuliang; Li, Zhiqiang; Yang, Shuangyi; Wang, Feilong; Gao, Tian; Zhou, Lei; Wang, Deshou; Sun, Lina

doi:10.1016/j.cbpb.2021.110674

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…Herein, we investigated Jarid2b gene expression patterns in adult Nile tilapia tissues and revealed differential expression levels in various tissues, which is consistent with the obtained expression pattern based on transcriptome data in Nile tilapia [ 49 ]. There is a variety of evidence that Jarid2 is widely expressed and has different biological functions in other species.…”

Section: Discussionsupporting

confidence: 68%

Molecular Cloning and Expression Responses of Jarid2b to High-Temperature Treatment in Nile Tilapia (Oreochromis niloticus)

Zhou

Yao

Zhao

et al. 2022

Genes

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Nile tilapia is a GSD + TE (Genetic Sex Determination + Temperature Effect) fish, and high-temperature treatment during critical thermosensitive periods (TSP) can induce the sex reversal of Nile tilapia genetic females, and brain transcriptomes have revealed the upregulation of Jarid2 (Jumonji and AT-rich domain containing 2) expression after 36 °C high-temperature treatment for 12 days during TSP. It was shown that JARID2 forms a complex with polycomb repressive complex 2 (PRC2) that catalyzed H3K27me3, which was strongly associated with transcriptional repression. In this study, Jarid2b was cloned and characterized in Nile tilapia, which was highly conserved among the analyzed fish species. The expression of Jarid2b was upregulated in the gonad of 21 dpf XX genetic females after 12-day high-temperature treatment and reached a similar level to that of males. Similar responses to high-temperature treatment also appeared in the brain, heart, liver, muscle, eye, and skin tissues. Interestingly, Jarid2b expression was only in response to high-temperature treatment, and not to 17α-methyltestosterone (MT) or letrozole treatments; although, these treatments can also induce the sex reversal of genetic Nile tilapia females. Further studies revealed that Jarid2b responded rapidly at the 8th hour after high-temperature treatment. Considering that JARID2 can recruit PRC2 and establish H3K27me3, we speculated that it might be an upstream gene participating in the regulation of Nile tilapia GSD + TE through regulating the H3K27 methylation level at the locus of many sex differentiation-related genes.

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Section: Discussionsupporting

confidence: 68%

Molecular Cloning and Expression Responses of Jarid2b to High-Temperature Treatment in Nile Tilapia (Oreochromis niloticus)

Zhou

Yao

Zhao

et al. 2022

Genes

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“…Along this line, bone marrow hypercellularity have been described in 2-year-old male offspring, developmentally exposed to BPA in the CLARITY-BPA program 11 . Notably, and according extensive feminization, the second ranked DET maps to Hspbap1, normally expressed in ovaries, which is upregulated in BPA exposed male rats and linked to sex reversal activity 44 . In addition, upregulation of Trat1 correlates with T cell activation, which also fits with a sex-reversal phenotype, since normally females produce more T cells.…”

Section: Discussionmentioning

confidence: 99%

Extensive transcriptome sex-reversal later in life, after developmental low-dose bisphenol A exposure

Dunder

Lejonklou

Lind³

et al. 2023

Preprint

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Bisphenol A (BPA) is an endocrine disruptor and exposure to low doses in utero has been associated with the development of metabolic diseases. Previous work indicated that bone marrow (BM) might be extra sensitive to BPA exposure1. Here we investigate how developmental exposure to low levels of BPA affect the BM transcriptome and the blood metabolic profile, together with how it compares to human metabolic syndrome (MetS) using a population-based cohort. The results show an unexpectedly extensive sex-reversal effect on the BM transcriptome from a BPA dose approximately eight times lower than the temporary European Food Safety Authority (EFSA) human tolerable daily intake (TDI) dose, similarly as a 100-times higher dose, considered safe in 2015(2). BPA appeared to induce, in males, while repress in females, gene expression in general and in T cells in particular, resulting in a hypometabolic cancer-like state in females and a hypermetabolic autoimmunity-like state in males, with a blood metabolic profile that significantly overlaps with human MetS. We conclude that developmental low-dose BPA exposure can cause extensive sex-reversal of transcription together with a sex-specific metabolic syndrome later in life, possibly through effects on T cell activity. Our study provide biologically plausible and convincing evidence for significant effects from low-dose BPA exposure3 and support the proposed substantial lowering of the human BPA TDI by EFSA4.

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Lysine Demethylase 1B Promotes Tear Secretion Disorder in Sjogren’s Syndrome by Regulating the PAX6/CLU Axis

et al. 2022

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Genome-wide identification, evolution of histone lysine demethylases (KDM) genes and their expression during gonadal development in Nile tilapia

Cited by 4 publications

References 46 publications

Molecular Cloning and Expression Responses of Jarid2b to High-Temperature Treatment in Nile Tilapia (Oreochromis niloticus)

Molecular Cloning and Expression Responses of Jarid2b to High-Temperature Treatment in Nile Tilapia (Oreochromis niloticus)

Extensive transcriptome sex-reversal later in life, after developmental low-dose bisphenol A exposure

Lysine Demethylase 1B Promotes Tear Secretion Disorder in Sjogren’s Syndrome by Regulating the PAX6/CLU Axis

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