2019
DOI: 10.1590/0074-02760190052
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Abstract: BACKGROUND Biomphalaria glabrata is the major species used for the study of schistosomiasis-related parasite-host relationships, and understanding its gene regulation may aid in this endeavor. The ubiquitin-proteasome system (UPS) performs post-translational regulation in order to maintain cellular protein homeostasis and is related to several mechanisms, including immune responses. OBJECTIVE The aims of this work were to identify and characterise the put… Show more

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Cited by 3 publications
(1 citation statement)
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References 33 publications
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“…Ubiquitin has furthermore been associated with cancer, neurodegenerative and autoimmune diseases [150][151][152], while in Mollusca, ubiquitin has been found to play roles in regulating synaptic strength and growth, using the sea slug (Aplysia) model [153]. In Mollusca, the ubiquitin-proteasome system has also been studied in relation to Schistosoma-snail pathogen-host interactions in Biomphalaria glabrata [154]. Deimination of ubiquitin was recently identified for the first time in Crustacea [48] and is here reported for the first time in Mollusca, indicating post-translational regulatory roles of ubiquitin related processes via deimination across different taxa.…”
Section: Discussionmentioning
confidence: 99%
“…Ubiquitin has furthermore been associated with cancer, neurodegenerative and autoimmune diseases [150][151][152], while in Mollusca, ubiquitin has been found to play roles in regulating synaptic strength and growth, using the sea slug (Aplysia) model [153]. In Mollusca, the ubiquitin-proteasome system has also been studied in relation to Schistosoma-snail pathogen-host interactions in Biomphalaria glabrata [154]. Deimination of ubiquitin was recently identified for the first time in Crustacea [48] and is here reported for the first time in Mollusca, indicating post-translational regulatory roles of ubiquitin related processes via deimination across different taxa.…”
Section: Discussionmentioning
confidence: 99%