Genome-wide identification and functional annotation of miRNAs in anti-inflammatory plant and their cross-kingdom regulation in <i>Homo sapiens</i>

Sharma, Ankita; Sahu, Sarika; Kumari, Pooja; Gopi, Soundhararajan; Malhotra, Rajesh; Biswas, S. N.

doi:10.1080/07391102.2016.1185381

Cited by 34 publications

(21 citation statements)

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“…Besides various in vitro and in vivo studies, two recent in silico analyses also strengthened cross-kingdom gene regulation [39,40]. In these reports, the miRNAs were predicted from the available EST datasets of important medicinal plants happy tree (Camptotheca acuminata) [39] and Curcuma longa [40]. In happy tree, the identified miRNAs were predicted to be targeting the cancer associated genes of human and their regulation of expression.…”

Section: In Silico Analysis Of Exogenous Plant Mirnasmentioning

confidence: 97%

“…The stability of miRNAs is due to unique sequence and high GC content in addition to its methylation [35]. Besides various in vitro and in vivo studies, two recent in silico analyses also strengthened cross-kingdom gene regulation [39,40]. In these reports, the miRNAs were predicted from the available EST datasets of important medicinal plants happy tree (Camptotheca acuminata) [39] and Curcuma longa [40].…”

Section: In Silico Analysis Of Exogenous Plant Mirnasmentioning

confidence: 99%

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Dietary plant miRNAs as an augmented therapy: cross-kingdom gene regulation

et al. 2018

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Cross-kingdom gene regulation by microRNAs (miRNAs) initiated a hot debate on the effective role of orally acquired plant miRNAs on human gene expression. It resulted in the expansion of gene regulation theories and role of plant miRNAs in cross-kingdom regulation of gene expression. This opened up the discussion that 'Whether we really get what we eat?' and 'Whether the orally acquired miRNAs really have a biologically important consequences after entering our digestive and circulatory system?' The reports of orally acquired plant miRNAs inside human alimentary canal have been a topic of discussion in the scientific community. The cross-kingdom gene regulations have raised our hopes to explore the exciting world of plant miRNAs as therapeutic potential and dietary supplements. However, there are reports which have raised concerns over any such cross-kingdom regulation and argued that technical flaws in the experiments might have led to such hypothesis. This review will give the complete understanding of exogenous application and cross-kingdom regulation of plant miRNAs on human health. Here, we provide update and discuss the consequences of plant miRNA mediated cross-kingdom gene regulation and possibilities for this exciting regulatory mechanism as an augmented therapy against various diseases. ARTICLE HISTORY

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Section: In Silico Analysis Of Exogenous Plant Mirnasmentioning

confidence: 97%

Section: In Silico Analysis Of Exogenous Plant Mirnasmentioning

confidence: 99%

Dietary plant miRNAs as an augmented therapy: cross-kingdom gene regulation

et al. 2018

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“…So far, compelling evidence has demonstrated that plant miRNAs are present in human/animal plasma and these miRNAs usually belong to evolutionary conserved families (Vaucheret and Chupeau, 2012; Zhang et al, 2012; Liang et al, 2014; Yang et al, 2015a; Yang et al, 2015b; Cavalieri et al, 2016). Plant miRNAs not only from edible plant species (rice, cabbage, broccoli, watermelon, soybean, strawberry, olive) but also from model (Arabidopsis, poplar) and medicinal plants (Moringa, honeysuckle, turmeric, ginger) had been evaluated for their potential trans -kingdom transfer (Zhang et al, 2012; Liang et al, 2014; Zhou et al, 2015; Cavalieri et al, 2016; Chin et al, 2016; Pirrò et al, 2016; Liu et al, 2017; Sharma et al, 2017; Minutolo et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

A Bioinformatics Approach to Explore MicroRNAs as Tools to Bridge Pathways Between Plants and Animals. Is DNA Damage Response (DDR) a Potential Target Process?

et al. 2019

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MicroRNAs, highly-conserved small RNAs, act as key regulators of many biological functions in both plants and animals by post-transcriptionally regulating gene expression through interactions with their target mRNAs. The microRNA research is a dynamic field, in which new and unconventional aspects are emerging alongside well-established roles in development and stress adaptation. A recent hypothesis states that miRNAs can be transferred from one species to another and potentially target genes across distant species. Here, we propose to look into the trans-kingdom potential of miRNAs as a tool to bridge conserved pathways between plant and human cells. To this aim, a novel multi-faceted bioinformatic analysis pipeline was developed, enabling the investigation of common biological processes and genes targeted in plant and human transcriptome by a set of publicly available Medicago truncatula miRNAs. Multiple datasets, including miRNA, gene, transcript and protein sequences, expression profiles and genetic interactions, were used. Three different strategies were employed, namely a network-based pipeline, an alignment-based pipeline, and a M. truncatula network reconstruction approach, to study functional modules and to evaluate gene/protein similarities among miRNA targets. The results were compared in order to find common features, e.g., microRNAs targeting similar processes. Biological processes like exocytosis and response to viruses were common denominators in the investigated species. Since the involvement of miRNAs in the regulation of DNA damage response (DDR)-associated pathways is barely explored, especially in the plant kingdom, a special attention is given to this aspect. Hereby, miRNAs predicted to target genes involved in DNA repair, recombination and replication, chromatin remodeling, cell cycle and cell death were identified in both plants and humans, paving the way for future interdisciplinary advancements.

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“…Later on, the levels of other plant‐derived miRNAs, such as miR172 from Brassica oleracea ; MIR2911 from the honeysuckle; mol‐miR166i, mol‐miR393c, and mol‐miR168a from Moringa oleifera ; and clo‐mir‐14 from Curcuma longa were experimentally determined by quantitative real‐time PCR (qRT‐PCR). These miRNAs were found to regulate inflammation, immune tolerance, tumour necrosis factor alpha (TNF‐α) expression, antiviral activity against influenza, and inhibition of SIRT1, which is involved in the regulation of human prostate, colon cancer, and acute myeloid leukemia in humans . Further, Chin et al recently reported that the plant‐derived miR159 can inhibit cancer growth in mice.…”

Section: Introductionmentioning

confidence: 99%