Genome-Wide Identification and Characterization of Tyrosine Kinases in the Silkworm, Bombyx mori

He, Songzhen; Tong, Xiaoling; Han, Minjin; Bai, Yanmin; Dai, Fangyin

doi:10.3390/ijms19040934

Cited by 4 publications

(3 citation statements)

References 68 publications

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“…BmAbl1 is one of the potential targets in candidate regions. A recent report suggested that BmAbl1 had a strong correlation with cocoon shell weight [9,10]. However, how BmAbl1 affects the synthesis of silk protein is still unknown.…”

Section: Discussionmentioning

confidence: 99%

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BmAbl1 Regulates Silk Protein Synthesis via Glutathione Metabolism in Bombyx mori

Qin

Sun

Zhang

et al. 2022

Insects

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Bombyx mori, domesticated from wild silkworms, is an economic insect that feeds on mulberry leaves and produces silk. In the current study, we demonstrated the contribution of BmAbl1 in silk protein synthesis. The inhibition and knockout of BmAbl1 can reduce the larva weight and CSW. The effect on CSW of BmAbl1 is not on the transcriptional level, but on the translational level. RNA-sequencing data suggested that amino acid synthesis and the metabolism process had a great difference between the BmAbl1- and Control strain, particularly glutathione metabolism. An abnormality in glutathione metabolism led to the reduction of free glycine and serine content, which are the main components of fibroin protein. Finally, fibroin protein synthesis has been reduced, including fibroin-heavy chain, fibroin-light chain, and p25 protein. This finding brought to light the role of BmAbl1 in the silk protein synthesis process.

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Section: Discussionmentioning

confidence: 99%

“…Insects 2022, 13, 967 2 of 13 Within this QTL region, the tyrosine protein kinase, BmAbl1, is considered a potential target gene affecting CSW [9,10].…”

Section: Introductionmentioning

confidence: 99%

BmAbl1 Regulates Silk Protein Synthesis via Glutathione Metabolism in Bombyx mori

Qin

Sun

Zhang

et al. 2022

Insects

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“…Comparing the EeTK genes with the TKs of human and zebrafish, the majority of their features appear to be largely stable, including subfamily numbers and sequence characteristics. 50,51 Most metazoan genomes encode 30 TK subfamilies, although the total number of TKs representing each subfamily of orthologues varies among different lineages (Figure 4, 90 in humans, 122 in zebrafish and 114 in the electric eel). Because the conservation of gene family size across multiple species may reflect specific functional constraints, 52,53 this observation is consistent with our TK identification results in the electric eel.…”

Section: Evolutionary Relationships Within the Vertebrate Tk Repertoirementioning

confidence: 99%

Genomic Survey of Tyrosine Kinases Repertoire inElectrophorus electricusWith an Emphasis on Evolutionary Conservation and Diversification

Liu

et al. 2020

Evol Bioinform Online

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Tyrosine kinases (TKs) play key roles in the regulation of multicellularity in organisms and involved primarily in cell growth, differentiation, and cell-to-cell communication. Genome-wide characterization of TKs has been conducted in many metazoans; however, systematic information regarding this superfamily in Electrophorus electricus (electric eel) is still lacking. In this study, we identified 114 TK genes in the E electricus genome and investigated their evolution, molecular features, and domain architecture using phylogenetic profiling to gain a better understanding of their similarities and specificity. Our results suggested that the electric eel TK (EeTK) repertoire was shaped by whole-genome duplications (WGDs) and tandem duplication events. Compared with other vertebrate TKs, gene members in Jak, Src, and EGFR subfamily duplicated specifically, but with members lost in Eph, Axl, and Ack subfamily in electric eel. We also conducted an exhaustive survey of TK genes in genomic databases, identifying 1674 TK proteins in 31 representative species covering all the main metazoan lineages. Extensive evolutionary analysis indicated that TK repertoire in vertebrates tended to be remarkably conserved, but the gene members in each subfamily were very variable. Comparative expression profile analysis showed that electric organ tissues and muscle shared a similar pattern with specific highly expressed TKs (ie, epha7, musk, jak1, and pdgfra), suggesting that regulation of TKs might play an important role in specifying an electric organ identity from its muscle precursor. We further identified TK genes exhibiting tissue-specific expression patterns, indicating that members in TKs participated in subfunctionalization representing an evolutionary divergence required for the performance of different tissues. This work generates valuable information for further gene function analysis and identifying candidate TK genes reflecting their unique tissue-function specializations in electric eel.

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Development of productive multi-viral disease-tolerant bivoltine silkworm breeds of Bombyx mori (Lepidoptera: Bombycidae)

et al. 2022

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Genome-Wide Identification and Characterization of Tyrosine Kinases in the Silkworm, Bombyx mori

Cited by 4 publications

References 68 publications

BmAbl1 Regulates Silk Protein Synthesis via Glutathione Metabolism in Bombyx mori

BmAbl1 Regulates Silk Protein Synthesis via Glutathione Metabolism in Bombyx mori

Genomic Survey of Tyrosine Kinases Repertoire inElectrophorus electricusWith an Emphasis on Evolutionary Conservation and Diversification

Development of productive multi-viral disease-tolerant bivoltine silkworm breeds of Bombyx mori (Lepidoptera: Bombycidae)

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