Genome-Wide Epigenomic Analyses in Patients With Nociceptive and Neuropathic Chronic Pain Subtypes Reveals Alterations in Methylation of Genes Involved in the Neuro-Musculoskeletal System

Stenz, Ludwig; Carré, Joane Le; Lüthi, François; Vuistiner, Philippe; Burrus, Cyrille; Paoloni-Giacobino, Ariane; Léger, Bertrand

doi:10.1016/j.jpain.2021.09.001

Cited by 13 publications

(13 citation statements)

References 56 publications

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“…As mentioned above, pain is defined as physical suffering or discomfort caused by illness or injury. Figure 2 compares the three different types of pain that can be experienced: nociceptive, inflammatory, and neuropathic [5]. Certain disease processes may involve a combination of the three types of pain making for a challenge in the management, acutely or chronically.…”

Section: Nociceptive Inflammatory and Neuropathicmentioning

confidence: 99%

“…Certain disease processes may involve a combination of the three types of pain making for a challenge in the management, acutely or chronically. Nociceptive and inflammatory pain can be classified as acute pain whereas neuropathic and nociceptive pain can develop into chronicity [5]. Acute pain is defined as pain experienced for a short period of time, usually following surgery, trauma, or other conditions that occur suddenly [6].…”

Section: Nociceptive Inflammatory and Neuropathicmentioning

confidence: 99%

“…Reference [5] Research has shown physiological processes modify pain experience, though in most studies, the anatomy and physiology of pain were investigated by studying cutaneous pain, while most chief complaints of pain in the healthcare setting arise from deep tissues [7,8]. What is known about primary afferent nociceptors comes from studies conducted on cutaneous nerves [7].…”

Section: Figure 2: Types Of Pain -Nociceptive Inflammatory and Neurop...mentioning

confidence: 99%

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Epigenetics and Pain: New Insights to an Old Problem

Nirvanie-Persaud¹,

Millis²

2022

Cureus

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Physicians and neuroscientists have long observed that factors such as thoughts, emotions, and expectations can influence the perception of pain. Pain can be described as an unpleasant sensation that causes physical discomfort and emotional distress. It alerts an individual to seek help and is the main complaint that brings individuals to physicians. Though it is associated with probable tissue damage, such damage may be subtle, sometimes involving the release of algesic chemicals, and also influenced by attitudes, beliefs, personality, and social factors. The perception of pain may vary due to a multitude of these factors influencing the ascending sensory impulse propagation to the primary somatosensory cortex. The genetics and epigenetics of pain modulators have been previously studied, but there is a lack of application in the everyday management and treatment of pain due to the paucity of valid evidence-based data. We used the PubMed database as our primary tool for researching current literature on this topic. The MeSH terms used included: gene modification, epigenetics, genes, pain, analgesia, "types of pain, and theories of pain. The results were filtered as follows: publications within the last 10 years, generalized pain studies regarding the biopsychosocial aspect of pain, pertinent genes, and epigenetic modulation of those genes; 52 publications were selected for review. By addressing the external factorial causes and the appropriate application of epigenetic principles which affect pain perception, it is hoped that this review will motivate future advancements in the management of acute and/or chronic pain.

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Section: Nociceptive Inflammatory and Neuropathicmentioning

confidence: 99%

Section: Nociceptive Inflammatory and Neuropathicmentioning

confidence: 99%

Section: Figure 2: Types Of Pain -Nociceptive Inflammatory and Neurop...mentioning

confidence: 99%

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Epigenetics and Pain: New Insights to an Old Problem

Nirvanie-Persaud¹,

Millis²

2022

Cureus

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“…Analysing the differentially methylated regions from circulating blood has proven useful in the clinic to identify pain biomarkers [ 46 ], to differentiate methylome signatures in different types of chronic pain [ 45 ], and to identify differential pain sensitivity [ 47 ]. However, excluding some exceptions [ 47 ], most methylome changes assessed in clinics are performed from circulating samples (e.g., blood) while the nociceptive pathway is not accounted for.…”

Section: Dna Methylation and Painmentioning

confidence: 99%

“…Gölzenleuchter and colleagues used this technique to identify genome-wide methylation changes at DRG of rats one day after the induction of a SNL which in some cases corresponded with changes at a transcriptional level [ 39 ]. Clinically, it has been used to identify blood biomarkers of inflammation and bone maturation in individuals suffering from chronic lower back pain [ 46 ] and the similarities (neuro-musculoeskeletal genes) and differences (opioid and GABAergic systems) between chronic nociceptive/neuropathic pain [ 45 ].…”

Section: Dna Methylation and Painmentioning

confidence: 99%

DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain

Irfan

Febrianto

Sharma

et al. 2022

IJMS

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While about half of the population experience persistent pain associated with tissue damages during their lifetime, current symptom-based approaches often fail to reduce such pain to a satisfactory level. To provide better patient care, mechanism-based analgesic approaches must be developed, which necessitates a comprehensive understanding of the nociceptive mechanism leading to tissue injury-associated persistent pain. Epigenetic events leading the altered transcription in the nervous system are pivotal in the maintenance of pain in tissue injury. However, the mechanisms through which those events contribute to the persistence of pain are not fully understood. This review provides a summary and critical evaluation of two epigenetic mechanisms, DNA methylation and non-coding RNA expression, on transcriptional modulation in nociceptive pathways during the development of tissue injury-associated pain. We assess the pre-clinical data and their translational implication and evaluate the potential of controlling DNA methylation and non-coding RNA expression as novel analgesic approaches and/or biomarkers of persistent pain.

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Smart Response Biomaterials for Pain Management

Zhang,

Guan,

et al. 2024

Adv Healthcare Materials

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The intricate nature of pain classification and mechanism constantly affects the recovery of diseases and the well‐being of patients. Key medical challenges persist in devising effective pain management strategies. Therefore, a comprehensive review of relevant methods and research advancements in pain management is conducted. This overview covers the main categorization of pain and its developmental mechanism, followed by a review of pertinent research and techniques for managing pain. These techniques include commonly prescribed medications, invasive procedures, and noninvasive physical therapy methods used in rehabilitation medicine. Additionally, for the first time, a systematic summary of the utilization of responsive biomaterials in pain management is provided, encompassing their response to physical stimuli such as ultrasound, magnetic fields, electric fields, light, and temperature, as well as changes in the physiological environment like reactive oxygen species (ROS) and pH. Even though the application of responsive biomaterials in pain management remains limited and at a fundamental level, recent years have seen the examination and debate of relevant research findings. These profound discussions aim to provide trends and directions for future research in pain management.

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Genome-Wide Epigenomic Analyses in Patients With Nociceptive and Neuropathic Chronic Pain Subtypes Reveals Alterations in Methylation of Genes Involved in the Neuro-Musculoskeletal System

Abstract: Genome-wide epigenomic analyses in patients with nociceptive and neuropathic chronic pain subtypes reveals alterations in methylation of genes involved in the neuro-musculoskeletal system

Cited by 13 publications

References 56 publications

Epigenetics and Pain: New Insights to an Old Problem

Epigenetics and Pain: New Insights to an Old Problem

DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain

Smart Response Biomaterials for Pain Management

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