Genome-wide DNA methylation, imprinting, and gene expression in human placentas derived from Assisted Reproductive Technology
P Auvinen,
J Vehviläinen,
K Rämö
et al.
Abstract:Assisted reproductive technology (ART) has been associated with increased risk for growth disturbance and imprinting disorders, but the molecular mechanisms and whether they are a result of the ART procedures or the underlying subfertility are unknown. Here we performed genome-wide DNA methylation analysis by EPIC Illumina microarrays and gene expression analysis by mRNA sequencing for a total of 80 ART and 77 control placentas, including separate procedure- and sex-specific analyses. ART-associated changes en… Show more
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