Genome-wide DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia in the Chinese Han population

Li, Mingrui; Li, Yanli; Qin, Haide; Tubbs, Justin D.; Li, Minghui; Qiao, Chunhong; Lin, Jinran; Li, Qingyang; Fan, Fengmei; Gou, Mengzhuang; Huang, Junchao; Tong, Jinghui; Yang, Fude; Tan, Yunlong; Yao, Yin

doi:10.1038/s41380-020-00968-0

Cited by 31 publications

(33 citation statements)

References 54 publications

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“… 53 Notably, one study has revealed that the most significant differentially methylated positions in the Chinese cohort are the C17orf63 , THAP domain-containing protein 1 and potassium voltage-gated channel subfamily KQT member 4 genes. 54 …”

Section: Methodsmentioning

confidence: 99%

Consensus on potential biomarkers developed for use in clinical tests for schizophrenia

et al. 2022

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BackgroundSchizophrenia is a serious mental illness affecting approximately 20 million individuals globally. Both genetic and environmental factors contribute to the illness. If left undiagnosed and untreated, schizophrenia results in impaired social function, repeated hospital admissions, reduced quality of life and decreased life expectancy. Clinical diagnosis largely relies on subjective evidence, including self-reported experiences, and reported behavioural abnormalities followed by psychiatric evaluation. In addition, psychoses may occur along with other conditions, and the symptoms are often episodic and transient, posing a significant challenge to the precision of diagnosis. Therefore, objective, specific tests using biomarkers are urgently needed for differential diagnosis of schizophrenia in clinical practice.AimsWe aimed to provide evidence-based and consensus-based recommendations, with a summary of laboratory measurements that could potentially be used as biomarkers for schizophrenia, and to discuss directions for future research.MethodsWe searched publications within the last 10 years with the following keywords: ‘schizophrenia’, ‘gene’, ‘inflammation’, ‘neurotransmitter’, ‘protein marker’, ‘gut microbiota’, ‘pharmacogenomics’ and ‘biomarker’. A draft of the consensus was discussed and agreed on by all authors at a round table session.ResultsWe summarised the characteristics of candidate diagnostic markers for schizophrenia, including genetic, inflammatory, neurotransmitter, peripheral protein, pharmacogenomic and gut microbiota markers. We also proposed a novel laboratory process for diagnosing schizophrenia in clinical practice based on the evidence summarised in this paper.ConclusionsFurther efforts are needed to identify schizophrenia-specific genetic and epigenetic markers for precise diagnosis, differential diagnosis and ethnicity-specific markers for the Chinese population. The development of novel laboratory techniques is making it possible to use these biomarkers clinically to diagnose disease.

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Section: Methodsmentioning

confidence: 99%

Consensus on potential biomarkers developed for use in clinical tests for schizophrenia

et al. 2022

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“…Analysis of previous EWAS has revealed 23 genes that were differentially methylated across these EWAS on schizophrenia, such as CACNB2 and PRKN ( Forero and Gonzalez-Giraldo, 2020 ). In the Chinese Han population, it has been revealed that the most significant DMPs were pinned to genes C17orf53 , THAP1 , and KCNQ4 in patients with first-episode schizophrenia ( Li et al, 2020 ). In addition, the top-ranked differentially methylated regions (DMRs) overlapped the major histocompatibility complex (MHC), which has been shown to closely associate with schizophrenia, and schizophrenia patients presented higher polygenic risk score (PRS) compared with controls ( Hannon et al, 2016 ).…”

Section: The Association Between Dna Methylation and Schizophreniamentioning

confidence: 99%

Research Progress on the Correlation Between Epigenetics and Schizophrenia

Chen

Jin

et al. 2021

Front. Neurosci.

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Purpose of the ReviewNowadays, the incidence of schizophrenia is noticeably increased. If left undiagnosed and untreated, it will lead to impaired social functions, repeated hospital admissions, decline in quality of life and life expectancy. However, the diagnosis of schizophrenia is complicated and challenging. Both genetic and environmental factors are considered as important contributors to the development and progression of this disorder. The environmental factors have been linked to changes in gene expression through epigenetic modulations, which have raised more and more research interests in recent years. This review article is to summarize the current findings and understanding of epigenetic modulation associated with pathogenesis of schizophrenia, aiming to provide useful information for further research in developing biomarkers for schizophrenia.Recent FindingsThree major types of epigenetic modulations have been described in this article. Firstly, both DNA hypermethylation and hypomethylated have been associated with schizophrenia via analyzing post-mortem brain tissues and peripheral blood of patients. Specific changes of non-coding RNAs, particularly microRNAs and long-chain non-coding RNAs, have been observed in central and peripheral samples of schizophrenia patients, indicating their significant diagnostic value for the disease, and may also potentially predict treatment response. The correlation between histone modification and schizophrenia, however, is largely unclear.SummaryEpigenetic modulations, including DNA methylation, ncRNA transcriptional regulation and histone modification, play an important role in the pathogenesis of schizophrenia. Therefore, tests of these epigenetic alterations may be utilized to assist in the diagnosis and determination of strategies of individualized treatment in clinical practice.

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“…B. DNA-Methylierung [ 26 ], Histon- und MicroRNA-Expression etc. ), welche durch Umweltfaktoren beeinflusst werden können, tragen zur Krankheitsentwicklung bei [ 27 , 28 ]. Biologische Datenbanken (inkl.…”

Section: Hintergrundunclassified

Sektorenübergreifende Therapiekonzepte und innovative Technologien: neue Möglichkeiten für die Versorgung von Patienten mit psychischen Erkrankungen

et al. 2021

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ZusammenfassungPsychische Erkrankungen sind weit verbreitet und ein bedeutendes Problem des allgemeinen Gesundheitswesens. Das Risiko, irgendwann im Laufe des Lebens eine psychische Erkrankung zu entwickeln, liegt bei rund 40 %. Psychische Erkrankungen zählen damit zu den epidemiologisch bedeutsamsten Erkrankungen. Trotz der Einführung neuerer Psychopharmaka, störungsspezifischer Psychotherapie und Stimulationstechniken zeigen viele der Betroffenen immer noch eine unzureichende Symptomremission und einen chronischen Verlauf. Durch den konzeptuellen und technischen Fortschritt der letzten Jahre wird eine neue, flexiblere und personalisierte Form der fachpsychiatrischen Patientenversorgung ermöglicht. Sowohl die traditionellen Therapie- und Organisationskonzepte als auch neuere dezentral arbeitende, modular aufgebaute, stationär-teilstationär-ambulante Einheiten werden zusammen mit innovativen digitalen Technologien vielen betroffenen Menschen mit psychischen Erkrankungen individualisierte Therapieoptionen bieten, welche ihre Symptome bestmöglich lindern und ihre Lebensqualität erheblich verbessern könnten. Das primäre Ziel der engen Verknüpfung von modernen Versorgungskonzepten und innovativen Technologien ist es, ein umfassendes Therapie- und Nachsorgekonzept (innerhalb und außerhalb der Klinik) für die individuellen Bedürfnisse von Menschen mit psychischer Erkrankung bereitzustellen. Nicht zuletzt wird dadurch auch eine ortsunabhängige Verfügbarkeit der fachärztlichen Behandlung erreicht. In der Psychiatrie des 21. Jahrhunderts müssen moderne Versorgungsstrukturen mit der aktuellen Dynamik der digitalen Transformation effektiv verknüpft werden. Die vorliegende selektive Übersichtsarbeit widmet sich den theoretischen und praktischen Gesichtspunkten eines sektorenübergreifenden Behandlungssystems kombiniert mit innovativen digitalen Technologien im psychiatrisch-psychotherapeutischen Fachbereich am Beispiel des Zentralinstituts für Seelische Gesundheit in Mannheim.

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Genome-wide DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia in the Chinese Han population

Cited by 31 publications

References 54 publications

Consensus on potential biomarkers developed for use in clinical tests for schizophrenia

Consensus on potential biomarkers developed for use in clinical tests for schizophrenia

Research Progress on the Correlation Between Epigenetics and Schizophrenia

Sektorenübergreifende Therapiekonzepte und innovative Technologien: neue Möglichkeiten für die Versorgung von Patienten mit psychischen Erkrankungen

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