Genome‐wide differential expression reveals candidate genes involved in the pathogenesis of lupus and lupus nephritis

Abstract

Our study provides central gene regulators of therapeutic potential, indicating the future prospects of the study.

RNA-sequencing study of peripheral blood mononuclear cells in sporadic Ménière's disease patients: possible contribution of immunologic dysfunction to the development of this disorder

“…In this study, we found that SLC4A10 and SLC4A1 were down-regulated significantly in MD. Recently, another SLC family member, SLC4A1, had been hypothesized to be a candidate gene in the pathogenesis of lupus and lupus nephritis, which stimulated the functional activity of innate immune cells and cell-specific functions [48]. Recently, another SLC family member, SLC4A1, had been hypothesized to be a candidate gene in the pathogenesis of lupus and lupus nephritis, which stimulated the functional activity of innate immune cells and cell-specific functions [48].…”

“…A previous report suggested that SLC4A10 participated in the regulation of pH homeostasis in leucocytes, which indicated that inflammation was associated with a local pH reduction and might be a 'danger signal' to activate immune responses [47]. Recently, another SLC family member, SLC4A1, had been hypothesized to be a candidate gene in the pathogenesis of lupus and lupus nephritis, which stimulated the functional activity of innate immune cells and cell-specific functions [48]. Interestingly, SLC4A1 was reported to be over-expressed significantly in the human endolymphatic sac, compared to adjacent dura mater [49], which was contrary to the result seen in our study.…”

MEditerranean FeVer ( MEFV ) gene mutations in glomerulonephritides: a clinicopathological study

“…Further genetic studies are needed to conclude properly on this issue. Genome-wide association studies in patients with IgA nephropathy and lupus nephritis did not reveal any association with the MEFV gene or chromosomal region 16p13 before (44,45). Notably, these were not whole-exome sequencing studies and the MEFV gene was not identified as a target gene in these studies.…”

Sex Differences in Correlation with Gene Expression Levels between Ifi200 Family Genes and Four Sets of Immune Disease-Relevant Genes

“…We next assessed genes with different expression levels in patients with SLE or RA and animal models of SLE, RA, and OA. These genes include Ets-1 and FoxP3 [ 32 ]; ITGAM and Fc γ RIIIA [ 33 ]; PD-1.3A , C4AQ0 , and MBL [ 34 ]; AlFadhli ( IRF9 , ABCA1 , APOBEC3 , CEACAM3 , OSCAR , TNFA1P6 , MMP9 , and SLC4A1 ) [ 35 ]; FCGR3A and FCGR3B [ 36 ]; Tlr7 [ 37 ]; TBX21 and IFNG [ 38 ]; CD95 and CCR7 [ 39 ]; Fkbp11 [ 40 ]; JHDM1D and HDAC1-3 [ 41 ]; IL-28RA [ 42 ]; and pSTAT1 and ETS1 [ 43 ]. For genes associated with arthritis, we used genes expressed in RA or OA [ 44 – 46 ].…”