Genome-wide cross-disease analyses highlight causality and shared biological pathways of type 2 diabetes with gastrointestinal disorders
Emmanuel Adewuyi,
Tenielle Porter,
Eleanor O’Brien
et al.
Abstract:Observational studies suggest links between diabetes and gastrointestinal (GI) traits; however, the question of their underlying biological mechanisms and whether the observed relationship reflects shared genetic aetiology remains unresolved. Here, we comprehensively assess the genetic relationship between type 2 diabetes (T2D) and common GI disorders, leveraging several large-scale genome-wide association studies (GWAS) summary statistics. Our study demonstrates a significant positive global genetic correlati… Show more
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