Genome‐wide association study reveals novel genes for the ear size in sheep (<i>Ovis aries</i>)

Gao, Lei; Xu, Song-Song; Yang, Jingquan; Shen, Min; Li, M.‐H.

doi:10.1111/age.12670

Cited by 28 publications

(32 citation statements)

References 17 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…), ears with different sizes (Gao et al . ) and microtia (this study)—could also be responsible for these discrepancies. Because the genetic basis of variable ear size is still not understood, further studies are needed to evaluate if microtia derives from different genetic factors in other sheep breeds.…”

Section: Suggestively Significant (005mentioning

confidence: 62%

“…; Gao et al . ). In the present study, to identify the potential causative genes involved in microtia in sheep, we performed a case–control GWAS and a genome F ST analysis in the Valle del Belice breed.…”

Section: Suggestively Significant (005mentioning

confidence: 97%

“…; Gao et al . ). Therefore, it can be hypothesized that variants of the CLRN1 gene could result in an underdevelopment of the ear.…”

Section: Suggestively Significant (005mentioning

confidence: 97%

“…Recently, Gao et al . (), in a GWAS using animals with different ear size (from 102.55 to 179.95 cm 2 ), showed a strong association with SNP rs402740419 (on OAR23), located within the DCC gene, and two additional SNPs located within two genes— PTPRD (on OAR2) and SOX5 (on OAR3)—in the Duolang Chinese native sheep breed. The authors did not observe association with the GATA6 gene.…”

Section: Suggestively Significant (005mentioning

confidence: 97%

See 3 more Smart Citations

Genome‐wide association study reveals the locus responsible for microtia in Valle del Belice sheep breed

et al. 2018

View full text Add to dashboard Cite

Microtia is a congenital deformity of the outer ear with phenotypes varying from a small auricle to total absence (anotia). The genetic basis is still poorly understood, and very few studies have been performed in sheep. Valle del Belice sheep is a breed showing microtia. The aim of this study was to identify the potential genomic regions involved in microtia in sheep. A total of 40 individuals, 20 with microtia and 20 normal, were genotyped with the Illumina OvineSNP50 BeadChip. The comparison among the results from a genome-wide association study, Fisher's exact test and F analysis revealed a single strong association signal: rs419889303 on chromosome 1, located within intron 3 of the CLRN1 gene. Our study suggests for the first time that this novel candidate gene is responsible for microtia in sheep. Additional analysis based on the sequencing would help confirm our findings and allow for the proposal of a precise genetic basis for microtia in sheep.

show abstract

Section: Suggestively Significant (005mentioning

confidence: 62%

Section: Suggestively Significant (005mentioning

confidence: 97%

“…; Gao et al . ). Therefore, it can be hypothesized that variants of the CLRN1 gene could result in an underdevelopment of the ear.…”

Section: Suggestively Significant (005mentioning

confidence: 97%

Section: Suggestively Significant (005mentioning

confidence: 97%

See 2 more Smart Citations

Genome‐wide association study reveals the locus responsible for microtia in Valle del Belice sheep breed

et al. 2018

View full text Add to dashboard Cite

show abstract

“…This hypothesis is supported by the fact that MSRB3 and LEMD3 were identified as candidate genes for ear morphology in dogs [26] and pigs [27]. Therefore, despite these genes having not been associated with the ear size [28], doubts on ascribing this signal to the fat-tail are obvious. A large region on OAR5:47.0-49.0 Mb (S3 Fig and Table 4) turned out here to encode putative fat deposition genes in the two groups of Ethiopian sheep: the one composed only by the long fat-tail, and the one including all the eleven Ethiopian fat-tail breeds.…”

Section: Discussionmentioning

confidence: 99%

Novel and known signals of selection for fat deposition in domestic sheep breeds from Africa and Eurasia

Mastrangelo¹,

Bahbahani²,

Moioli³

et al. 2018

Preprint

View full text Add to dashboard Cite

34Genomic regions subjected to selection frequently show signatures such as within-35 population reduced nucleotide diversity and outlier values of differentiation among differentially 36 selected populations. In this study, we analyzed 50K SNP genotype data of 373 animals belonging 37 to 23 sheep breeds of different geographic origins using the Rsb and F ST statistical approaches, to 38 identify loci associated with the fat-tail phenotype. We also checked if these putative selection 39 signatures overlapped with regions of high-homozygosity (ROH). The analyses identified novel 40 signals and confirmed the presence of selection signature in genomic regions that harbor candidate 41 genes known to affect fat deposition. Several genomic regions that frequently appeared in ROH 42 were also identified within each breed, but only two ROH islands overlapped with the putative 43 selection signatures. The results reported herein provide the most complete genome-wide study of 44 selection signatures for fat-tail in African and Eurasian sheep breeds; they also contribute insights 45 into the genetic basis for the fat tail phenotype in sheep, and confirm the great complexity of the 46 mechanisms that underlie quantitative traits, such as the fat-tail. 47 48 3 51been widely applied to livestock species to achieve more desirable/profitable phenotypes [1]. For 52 instance, sheep (Ovis aries) have been selected since domestication, approximately 9,000 years ago 53 [2]. This process of selection resulted in divergent sheep breeds, reared in different geographic 54 regions due to their different adaptability. Among these, fat-tail are an important class of sheep 55 breeds and represent about 25% of the world's sheep population [3] mainly distributed in the 56 Middle East, North and East Africa and Central Asia. According to Xu et al. [4] fat tails represent 57 the energy reserve necessary to survive critical conditions such as drought seasons and food 58 shortage. This statement being emphasized by Mwacharo et al. [5] who confirmed that the fat-tails 59 are the predominant sheep across the deserts of northern Africa, and in the highlands, semi-arid and 60 arid environments of eastern and southern Africa while the thin-tails occur in Sudan and in the sub-61 humid and humid regions of West Africa. 62The unique genetic patterns inscribed in the genome of individuals by natural and/or 63 artificial selection are defined as signatures of selection, which are usually regions of the genome 64 that harbor functionally important sequence variants [6]. Although human consumption of animal 65 fat has dramatically reduced in preference of leaner meat, the investigation of the potential 66 candidate genes involved in the fat-tail might contribute to exploring the genetics of fat deposition, 67 energy storage and adaptation to climate changes [7][8][9]. With the aim to identify candidate genes 68 with a potential role in these traits, several authors performed studies targeting the fat-tail 69 phenotype contrasted with the thi...

show abstract

A 76-base pair duplication within the enhancer region of the HMX1 gene causes sheep microtia

Zhang,

Liang,

Kasimu

et al. 2024

Gene

View full text Add to dashboard Cite

Genome‐wide association study reveals novel genes for the ear size in sheep (Ovis aries)

Cited by 28 publications

References 17 publications

Genome‐wide association study reveals the locus responsible for microtia in Valle del Belice sheep breed

Genome‐wide association study reveals the locus responsible for microtia in Valle del Belice sheep breed

Novel and known signals of selection for fat deposition in domestic sheep breeds from Africa and Eurasia

A 76-base pair duplication within the enhancer region of the HMX1 gene causes sheep microtia

Contact Info

Product

Resources

About