Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome

Tsetsos, Fotis; Topaloudi, Apostolia; Jain, Pritesh; Yang, Zhiyu; Yu, Dongmei; Kolovos, Petros; Tümer, Zeynep; Rizzo, Renata; Hartmann, Andreas; Depienne, Christel; Worbe, Yulia; Müller-Vahl, Kirsten; Cath, Daniëlle C.; Boomsma, Dorret I.; Wolańczyk, Tomasz; Żekanowski, Cezary; Barta, Csaba; Nemoda, Zsófia; Tárnok, Zsanett; Padmanabhuni, Shanmukha Sampath; Buxbaum, Joseph D.; Grice, Dorothy E.; Glennon, Jeffrey C.; Stefánsson, Hreinn; Hengerer, Bastian; Yannaki, Evangelia; Stamatoyannopoulos, J; Benaroya-Milshtein, Noa; Cardona, Francesco; Hedderly, Tammy; Heyman, Isobel; Huyser, Chaim; Mir, Pablo; Morer, Àstrid; Mueller, Norbert; Münchau, Alexander; Plessen, Kerstin Jessica; Porcelli, Cesare; Roessner, Veit; Walitza, Susanne; Schrag, Anette; Martino, Davide; Tischfield, Jay A.; Heiman, Gary A.; Willsey, A. Jeremy; Dietrich, Andrea; Davis, Lea K.; Crowley, James J.; Mathews, Carol A.; Scharf, Jeremiah M.; Georgitsi, Marianthi; Hoekstra, Pieter J.; Paschou, Peristera

doi:10.1016/j.biopsych.2023.01.023

Cited by 6 publications

(6 citation statements)

References 65 publications

(83 reference statements)

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“…Tetsos and colleagues performed the largest Tourette Syndrome GWAS meta-analysis to date with a total of 6,133 TS cases and 13,565 controls, including a novel dataset ( Tsetsos et al . 2023 ).…”

Section: Resultsmentioning

confidence: 99%

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Tourette syndrome research highlights from 2022

Hartmann,

Andrén,

Atkinson-Clément

et al. 2023

F1000Res

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Section: Resultsmentioning

confidence: 99%

“…Jain and colleagues used previous TS GWAS summary statistics ( Tsetsos et al . 2023 ) to calculate the TS Polygenic Risk Score (PRS) on individuals in the UK Biobank and then performed a Phenome Wide Association Study (PheWAS) to assess the association of TS genetic risk with a wide range of phenotypes (n = 2242) ( Jain et al .…”

Section: Resultsmentioning

confidence: 99%

Tourette syndrome research highlights from 2022

Hartmann,

Andrén,

Atkinson-Clément

et al. 2023

F1000Res

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“…NR2F1 is a nuclear receptor that is a regulator of transcription. Additional analyses exploring the association of TS polygenic risk score with brain volume data revealed statistically significant associations with right and left thalamus volumes and right putamen volume (Tsetsos et al 2023).…”

Section: Genetics and Epigeneticsmentioning

confidence: 92%

“…Jain and colleagues (2023) used TS GWAS summary statistics from Tsetsos and colleagues (Tsetsos et al 2023) to calculate the TS Polygenic Risk Score (PRS) on individuals in the UK Biobank and then performed a Phenome Wide Association Study (PheWAS) to assess the association of TS genetic risk with a wide range of phenotypes (n=2242). They identified significant associations with 57 traits including depression, anxiety disorder, respiratory conditions, type 2 diabetes and heart palpitations.…”

Section: Genetics and Epigeneticsmentioning

confidence: 99%

Tourette syndrome research highlights from 2023

Hartmann,

Andrén,

Atkinson-Clement

et al. 2024

F1000Res

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“…The conventional therapeutic approach to managing TS focuses on pharmacological treatment to mitigate the severity of tics[ 5 , 6 ]. However, medications such as antipsychotics, which is often used in treatment, can have a variety of adverse effects that may dissuade patients and their families from pursuing these options[ 7 ]. Given these challenges, alternative treatment modalities to address tics and the often-associated psychiatric comorbidities have been receiving increasing interest[ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of cognitive-behavioral therapy combined with habit reversal training on anxiety disorders in children with Tourette’s syndrome

Wang,

Zhang,

Han

2024

World J Psychiatry

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BACKGROUND Cognitive-behavioral therapy (CBT) and habit reversal training (HRT) have shown application potential in addressing tic symptoms and comorbid psychiatric conditions. Despite their theoretical potential, empirical evidence on their combined efficacy remains limited. AIM To evaluate the efficacy of CBT combined with HRT on anxiety disorders in children with Tourette’s syndrome (TS). METHODS Clinical data of children with TS admitted to our hospital from January 2022 to June 2023 were collected, and the patients were grouped into the conventional therapy (control) group and the CBT combined with HRT group. Baseline characteristics, anxiety scores, tic severity scores, treatment adherence, and parental satisfaction were assessed. Statistical analysis was performed using t-tests, chi-square tests, and correlation analysis. RESULTS A total of 136 patients, including 65 patients in the control group and 71 patients in the CBT combined with HRT group, were included. The CBT combined with HRT group showed remarkable improvements compared with the control group. Post-intervention assessment revealed a decrease in anxiety scores from 63.52 ± 1.81 to 40.53 ± 1.64 (t = 2.022, P = 0.045), and the Yale Global Tic Severity Scale total score decreased from 22.14 ± 5.67 to 16.28 ± 4.91 (t = 2.288, P = 0.024). Treatment adherence was significantly higher in the CBT combined with HRT group (85.47 ± 7.62%) compared with the control group (82.32 ± 6.54%; t = 2.596, P = 0.010). Parental satisfaction scores were also higher in the CBT combined with HRT group (8.69 ± 1.77) compared with the control group (7.87 ± 1.92; t = 2.592, P = 0.011). CONCLUSION This study demonstrates that CBT combined with HRT significantly reduces anxiety symptoms and tic severity in children with TS, with higher treatment adherence and parental satisfaction. These findings support the potential application of this comprehensive therapeutic approach for TS treatment.

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Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome

Cited by 6 publications

References 65 publications

Tourette syndrome research highlights from 2022

Tourette syndrome research highlights from 2022

Tourette syndrome research highlights from 2023

Efficacy of cognitive-behavioral therapy combined with habit reversal training on anxiety disorders in children with Tourette’s syndrome

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