Genome-wide association study of social relationship satisfaction: significant loci and correlations with psychiatric conditions

Warrier, Varun; Bourgeron, Thomas; Baron‐Cohen, Simon

doi:10.1101/196071

Cited by 3 publications

(1 citation statement)

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“…To identify if systemizing contributes to social autistic traits we conducted genetic correlation using the Social and Communication Disorder Checklist (SCDC), which is genetically correlated with autism 43 (Supplementary Note). Additionally, we also conducted genetic correlation between the SQ-R and family relationship satisfaction, friendship satisfaction 44 , and selfreport empathy which are negatively correlated with autism. We did not identify a significant genetic correlation between SQ-R and SCDC (r g = 0.04±0.18, P = 0.81), family relationship satisfaction (r g = -0.04 ± 0.06, P = 0.47), friendship satisfaction (r g = 0.06±0.07, P = 0.42), and 1 0 empathy (r g = 0.10±0.07, P = 0.17).…”

Section: Genetic Correlationmentioning

confidence: 99%

Social and non-social autism symptom and trait domains are genetically dissociable

Warrier

Toro

Won

et al. 2017

Preprint

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The hypersystemizing theory of autism suggests that autistic individuals, on average, have superior attention to detail, and a stronger drive to systemize. Systemizing involves identifying input-operation-output relationships. Here, we report the results of genome-wide association studies (GWAS) of systemizing measured using the Systemizing QuotientRevised in n = 51,564 individuals. We identify three genome-wide significant loci: Two of these were significant in the non-stratified GWAS: rs4146336 on chromosome 3 (P = 2.58x10 -8 ) and rs1559586 on chromosome 18 (P = 4.78x10 -8 ). In addition, we also identified a significant locus in the males-only GWAS (rs8005092 on chromosome 14, P = 3.74x10 -8 ).We find that 12%±1.2 of the variance in systemizing is captured by ). We identify a positive genetic correlation between autism and systemizing (r g = 0.26±0.06; P = 3.35x10 -5 ), which is independent of genetic contribution to educational attainment. We further demonstrate that genetic risk for autism from systemizing is genetically distinct from genetic risk emerging from social autistic traits, suggesting distinct shared genetics between autism and social and non-social traits. Our results highlight the importance of considering both social and non-social autistic traits in elucidating the genetic architecture of autism.

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Section: Genetic Correlationmentioning

confidence: 99%

Social and non-social autism symptom and trait domains are genetically dissociable

Warrier

Toro

Won

et al. 2017

Preprint

Self Cite

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Linkage Disequilibrium Score Statistic Regression for Identifying Novel Trait Associations

Pettit

Amos

2022

Curr Epidemiol Rep

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Social and non-social autism symptoms and trait domains are genetically dissociable

et al. 2019

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The core diagnostic criteria for autism comprise two symptom domains – social and communication difficulties, and unusually repetitive and restricted behaviour, interests and activities. There is some evidence to suggest that these two domains are dissociable, though this hypothesis has not yet been tested using molecular genetics. We test this using a genome-wide association study ( N = 51,564) of a non-social trait related to autism, systemising, defined as the drive to analyse and build systems. We demonstrate that systemising is heritable and genetically correlated with autism. In contrast, we do not identify significant genetic correlations between social autistic traits and systemising. Supporting this, polygenic scores for systemising are significantly and positively associated with restricted and repetitive behaviour but not with social difficulties in autistic individuals. These findings strongly suggest that the two core domains of autism are genetically dissociable, and point at how to fractionate the genetics of autism.

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Genome-wide association study of social relationship satisfaction: significant loci and correlations with psychiatric conditions

Cited by 3 publications

References 53 publications

Social and non-social autism symptom and trait domains are genetically dissociable

Social and non-social autism symptom and trait domains are genetically dissociable

Linkage Disequilibrium Score Statistic Regression for Identifying Novel Trait Associations

Social and non-social autism symptoms and trait domains are genetically dissociable

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