Genome-wide association study of live body weight and body conformation traits in young Karachai goats

Selionova, Marina; Aibazov, Magomet; Mamontova, Tatiana; Malorodov, V.V.; Sermyagin, A.A.; Zinovyeva, Natalia; Easa, Ahmed A.

doi:10.1016/j.smallrumres.2022.106836

Cited by 4 publications

(2 citation statements)

References 51 publications

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“…In contrast to our observations, Pandya et al (2021) found that at six months of age, goats with BB genotypes had a superior body mass (P < 0.05) than those with AB genotypes in Surti Goats Singh et al (2015). observed similar ndings for body length in Sirohi and Barbari goats across all ages; however, statistical analysis failed to reveal signi cantly differ The same ndings were reported byEsen and Elmac (2022), who found that yearling lambs with the P1 variant of the growth Hormone Exon-5 (GHE5) gene have a higher body length (BL), wider leg girth, and lean cannon bone periphery (CBP) (P > 0.05), in comparison to lambs with the other variant (P2), whose body length is shorter and CBP is thicker Selionova et al (2022). revealed a favourable connection between the molecular marker among MSTN, HEG1, FGF10, FGF14, GHRH, and SLAIN genes linked to live body mass at age four months old.…”

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confidence: 59%

Genetic polymorphism of the growth hormone gene and their effects on growth metrics in the Assam Hill and Sirohi goats under subtropical climatic condition

Kumar

Kadirvel

Khargharia

et al. 2023

Preprint

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Growth hormone (GH) is a gene that regulates milk production, reproduction, and growth in animals. Therefore, the purpose of this study was to identify GH gene variations and their associations with growth metrics in Sirohi and Assam hill goats. We identified two polymorphic loci (GH1-HaeIII & GH2-HaeIII) which were connected to growth attributes in 161 animals of Assam hill (n = 114) and Sirohi (n = 47) goats using the methods of PCR-RFLP. According to PCR-RFLP results, the GH gene's GH1-HaeIII locus contains two alleles (A and B) and two genotypes (AA and AB), whereas the GH2-HaeIII locus contains two alleles (C and D) and two genotypes (CC and CD). In the two goat breeds, the allele frequencies of A and B were 0.36 − 0.28 and 0.64–0.72, respectively, while the frequencies of alleles C and D were 0.71 − 0.70 and 0.29–0.30. The polymorphic loci were demonstrated to be in a state of Hardy-Weinberg disequilibrium in both breeds of goats (P < 0.05). The growth characteristics of the Assam hill goat breed were shown to be correlated with GH gene variations. In both breeds, AB and CD genotypes displayed slightly higher values in most of the morphometric traits compared to AA and CC genotypes; however, only in Assam hill goats body length and chest girth were positively significant (P < 0.05). Hence, the AB and CD genotypes have been proposed as potential markers for improved growth parameters in the breeds that were tested. Therefore, we came to the view that the two variant loci of the GH gene will utilize as marker assisted selection for enhancing growth attributes in goats; however, more research with a bigger sample size is necessary to verify the validity of this conclusion.

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confidence: 59%

Genetic polymorphism of the growth hormone gene and their effects on growth metrics in the Assam Hill and Sirohi goats under subtropical climatic condition

Kumar

Kadirvel

Khargharia

et al. 2023

Preprint

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“…Other GWS genes when tested for all individuals with weight were SNTA1, CBFA2T2, TXNRD3, SPIDR, ZXDC, ZNF341, CERS3, and CHMP4B (Table S14). SNTA1 was found to be one of the closest associated genes with Live Body Weight (LBW) at 4 months in Karachai goats (Selionova et al 2022). CBFA2T2 is a key regulator of adipogenesis which affects obesity when the gene expressions are altered (Matulewicz et al 2017; Ali et al 2013; Luo et al 2020).…”

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confidence: 99%

Genotypic and phenotypic consequences of domestication in dogs

Sweetalana,

Mooney,

Szpiech

2024

Preprint

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Runs of homozygosity (ROH) are genomic regions that arise when two copies of an identical ancestral haplotype are inherited from parents with a recent common ancestor. In this study, we performed a novel comprehensive analysis to infer genetic diversity among dogs and quantified the association between ROH and non-disease phenotypes. We found distinct patterns of genetic diversity across clades of breed dogs and elevated levels of long ROH, compared to non-domesticated dogs. These high levels of FROH (inbreeding coefficient) are a consequence of recent inbreeding among domesticated dogs during breed establishment. We identified statistically significant associations between FROH and height, weight, lifespan, muscled, white head, white chest, furnish, and length of fur. After correcting for population structure, we identified more than 45 genes across the three examined quantitative traits that exceeded the threshold for suggestive significance, indicating significant polygenic inheritance for the complex quantitative phenotypes in dogs.

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Comparison of the statistical methods for genome-wide association studies on simulated quantitative traits of domesticated goats (Capra hircus L.)

Cebecí

Bayraktar

Gökçe

2023

Small Ruminant Research

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Genome-wide association study of live body weight and body conformation traits in young Karachai goats

Cited by 4 publications

References 51 publications

Genetic polymorphism of the growth hormone gene and their effects on growth metrics in the Assam Hill and Sirohi goats under subtropical climatic condition

Genetic polymorphism of the growth hormone gene and their effects on growth metrics in the Assam Hill and Sirohi goats under subtropical climatic condition

Genotypic and phenotypic consequences of domestication in dogs

Comparison of the statistical methods for genome-wide association studies on simulated quantitative traits of domesticated goats (Capra hircus L.)

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