Genome-Wide Association Study of Blood Pressure Traits by Hispanic/Latino Background: the Hispanic Community Health Study/Study of Latinos

Sofer, Tamar; Wong, Quenna; Hartwig, Fernando Pires; Taylor, Kent D.; Warren, Helen R.; Εvangelou, Εvangelos; Cabrera, Claudia; Levy, Daniel; Kramer, Holly; Lange, Leslie A.; Horta, Bernardo Lessa; Kerr, Kathleen F.; Reiner, Alex P.; Franceschini, Nora

doi:10.1038/s41598-017-09019-1

Cited by 26 publications

(26 citation statements)

References 42 publications

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“…Sample sizes ranged from 11,809 to 12,705. GWASs for blood count traits in the HCHS/SOL were reported in Hodonsky et al (2017), Jain et al (2017), and Schick et al (2016), and GWASs for blood pressure (BP) traits were reported in Sofer, Wong, et al (2017).…”

Section: Gwass In the Hchs/solmentioning

confidence: 99%

Generalizing polygenic risk scores from Europeans to Hispanics/Latinos

Grinde

Thornton

et al. 2018

Genetic Epidemiology

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100

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Polygenic risk scores (PRSs) are weighted sums of risk allele counts of single‐nucleotide polymorphisms (SNPs) associated with a disease or trait. PRSs are typically constructed based on published results from Genome‐Wide Association Studies (GWASs), and the majority of which has been performed in large populations of European ancestry (EA) individuals. Although many genotype‐trait associations have generalized across populations, the optimal choice of SNPs and weights for PRSs may differ between populations due to different linkage disequilibrium (LD) and allele frequency patterns. We compare various approaches for PRS construction, using GWAS results from both large EA studies and a smaller study in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL, n = 12 , 803). We consider multiple approaches for selecting SNPs and for computing SNP weights. We study the performance of the resulting PRSs in an independent study of Hispanics/Latinos from the Women’s Health Initiative (WHI, n = 3 , 582). We support our investigation with simulation studies of potential genetic architectures in a single locus. We observed that selecting variants based on EA GWASs generally performs well, except for blood pressure trait. However, the use of EA GWASs for weight estimation was suboptimal. Using non‐EA GWAS results to estimate weights improved results.

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Section: Gwass In the Hchs/solmentioning

confidence: 99%

Generalizing polygenic risk scores from Europeans to Hispanics/Latinos

Grinde

Thornton

et al. 2018

Genetic Epidemiology

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100

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“…We defined and used blood pressure outcomes as in the blood pressure GWAS study [ 10 ], with the additional exclusions of 165 individuals that withdrew consent for participation in genetic studies. Detailed description of the blood pressure measurement procedure is provided elsewhere.…”

Section: Methodsmentioning

confidence: 99%

“…We removed a single individual with negative PP value and winsorized two outlying extreme values to have the value of the mean +6 standard deviations of PP, calculated on the analyzed sample set. Compared to the GWAS reported in [ 10 ], this study sample had 162 fewer individuals, because these HCHS/SOL participants withdrew their consent for genetic studies.…”

Section: Methodsmentioning

confidence: 99%

“…Blood pressure is a strong risk factor for cardiovascular disease and has a known genetic component. Multiple genome-wide association studies (GWASs) have been carried out in populations of European [ 1 – 4 ], Asians/East Asian, [ 5 ] and African [ 6 – 8 ] ancestries, in Hispanics/Latinos, [ 9 , 10 ] including the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), and also in trans-ethnic settings. [ 11 – 14 ] GWAS tests the association of each “dose” of genotyped or imputed variant with a trait of interest.…”

Section: Introductionmentioning

confidence: 99%

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Admixture mapping in the Hispanic Community Health Study/Study of Latinos reveals regions of genetic associations with blood pressure traits

et al. 2017

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Admixture mapping can be used to detect genetic association regions in admixed populations, such as Hispanics/Latinos, by estimating associations between local ancestry allele counts and the trait of interest. We performed admixture mapping of the blood pressure traits systolic and diastolic blood pressure (SBP, DBP), mean arterial pressure (MAP), and pulse pressure (PP), in a dataset of 12,116 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Hispanics/Latinos have three predominant ancestral populations (European, African, and Amerindian), for each of which we separately tested local ancestry intervals across the genome. We identified four regions that were significantly associated with a blood pressure trait at the genome-wide admixture mapping level. A 6p21.31 Amerindian ancestry association region has multiple known associations, but none explained the admixture mapping signal. We identified variants that completely explained this signal. One of these variants had p-values of 0.02 (MAP) and 0.04 (SBP) in replication testing in Pima Indians. A 11q13.4 Amerindian ancestry association region spans a variant that was previously reported (p-value = 0.001) in a targeted association study of Blood Pressure (BP) traits and variants in the vitamin D pathway. There was no replication evidence supporting an association in the identified 17q25.3 Amerindian ancestry association region. For a region on 6p12.3, associated with African ancestry, we did not identify any candidate variants driving the association. It may be driven by rare variants. Whole genome sequence data may be necessary to fine map these association signals, which may contribute to disparities in BP traits between diverse populations.

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“…Interestingly, several NT polymorphisms, including BDNF rs6265 (Val66Met) [ 179 , 180 , 181 , 182 , 183 ], NGF rs11102930 [ 184 ] and rs78701042 [ 185 ], have been associated to increased risk of ACS and adverse outcome.…”

Section: Adipokinesmentioning

confidence: 99%

Depression and Cardiovascular Disease: The Viewpoint of Platelets

Amadio

Zara

Sandrini

et al. 2020

IJMS

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Depression is a major cause of morbidity and low quality of life among patients with cardiovascular disease (CVD), and it is now considered as an independent risk factor for major adverse cardiovascular events. Increasing evidence indicates not only that depression worsens the prognosis of cardiac events, but also that a cross-vulnerability between the two conditions occurs. Among the several mechanisms proposed to explain this interplay, platelet activation is the more attractive, seeing platelets as potential mirror of the brain function. In this review, we dissected the mechanisms linking depression and CVD highlighting the critical role of platelet behavior during depression as trigger of cardiovascular complication. In particular, we will discuss the relationship between depression and molecules involved in the CVD (e.g., catecholamines, adipokines, lipids, reactive oxygen species, and chemokines), emphasizing their impact on platelet activation and related mechanisms.

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Genome-Wide Association Study of Blood Pressure Traits by Hispanic/Latino Background: the Hispanic Community Health Study/Study of Latinos

Cited by 26 publications

References 42 publications

Generalizing polygenic risk scores from Europeans to Hispanics/Latinos

Generalizing polygenic risk scores from Europeans to Hispanics/Latinos

Admixture mapping in the Hispanic Community Health Study/Study of Latinos reveals regions of genetic associations with blood pressure traits

Depression and Cardiovascular Disease: The Viewpoint of Platelets

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