Genome-Wide Association Study of Angioedema Induced by Ace Inhibitors or Arbs in Sweden

Abstract

Clinical Therapeutics e76Volume 39 Number 8S habits, knowledge of NSAID by doctors, knowledge of Good Clinical Practice (GCP) recommendations. We then conducted a retrospective observational study in 154 patients aged 65 years or older who received at least one NSAID given orally between October 1 st and December 31 st of 2014, by means of a questionnaire including 34 validated evaluation criteria according to the current guidelines. Results: The 6 GPs did not frequently prescribe NSAID in their patients aged 65 years or older, due to the high number of co-prescribed drugs, renal or liver insufficiency, and the high risk of side effects in these patients. Their knowledge regarding the side effects, contra-indications and warnings of the various available NSAIDs are heterogeneous and none of the interviewed GPs were aware of available GCP recommendations regarding NSAIDs prescription and side effects prevention in older patients. 10.5% of the 154 patients had a prescription of at least one NSAID. However, this prescription was in agreement with the market authorization recommendation in only 72% of cases. Numerous gaps were identified between daily practice of these GPs and the available GCP recommendations, except for the recommendations regarding gastrointestinal side effects and contraindications of the NSAID, which were highly respected. Conclusions: GCP recommendations for NSAIDs prescription are unknown from prescribers and respect of these recommendations should be improved by means of a patient-dedicated follow-up file designed to optimize the management and prevention of NSAIDrelated side effects in daily practice.reGulaTory VariaNTS oTher ThaN VKORC1 rs9923231 may explaiN The effeCT oN warfariN DoSe Background: Warfarin is the most commonly used oral anticoagulant for thrombotic disorders and atrial fibrillation. The dose is influenced by CYP2C9 and VKORC1. CYP2C9 variants change the protein sequence, but VKORC1 variants are non-coding and thought to act through regulation of gene expression. Which VKORC1 variant that

Exome Sequencing Reveals Common and Rare Variants in F5 Associated With ACE Inhibitor and Angiotensin Receptor Blocker–Induced Angioedema

“…7,8 PREDICTION-ADR has established novel genetic biomarkers in the pharmacogenetics of statin intolerance. 9 In previous studies, genetic variants in the bradykinin pathway, bradykinin-degrading enzyme aminopeptidase P gene (XPNPEP2) 10,11 and type 2 bradykinin receptor gene (BDKRB2), have been associated with ACEI-induced and ARB-induced cough and angioedema. Other genes, serpin family E member 1 gene (SERPINE1) and the coagulation factor XII gene (F12), have been associated with hereditary angioedema.…”