Genome-Wide Association Study in NSAID-Induced Acute Urticaria/Angioedema in Spanish and Han Chinese Populations

Cornejo-García, José Antonio; Lb, Liou; Blanca‐López, Natalia; Doña, Inmaculada; Ch, Chen; Yc, Chou; Hp, Chuang; Wu, Jing; Yt, Chen; Plaza-Serón, María del Carmen; Mayorga, Cristobalina; Guéant-Rodriguez, R.-M.; Sc, Lin; Mj, Torres; Campo, Paloma; Rondón, Carmen; Laguna, José Julio; Fernández, J.; Jl, Guéant; Cantó, Gabriela; Blanca, Miguel; Mt, Lee

doi:10.2217/pgs.13.166

Cited by 32 publications

(33 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We recently conducted the only GWAS for NIUA using 2 independent populations from Spain and Taiwan [129]. Suggestive associations were found for 3 genetic clusters in the Spanish group (RIMS1, BICC1, and RAD51L1) and 1 region in the Han Chinese group (ABI3BP).…”

Section: Beyond the Candidate Gene Approachmentioning

confidence: 99%

See 1 more Smart Citation

Update on the Genetic Basis of Drug Hypersensitivity Reactions

Jurado‐Escobar¹,

Perkins²,

García‐Martín³

et al. 2017

J Investig Allergol Clin Immunol

View full text Add to dashboard Cite

Drug hypersensitivity reactions (DHRs) are unpredictable, complex responses to medicines in predisposed individuals. They represent a major health problem owing to the number of patients affected and the severity of the clinical conditions they can induce. In addition to environmental factors, the underlying mechanisms of DHRs are also influenced by genetic factors, although considerable gaps remain in our knowledge. Therefore, further study of the genetics of DHRs is necessary to shed light on their underlying mechanisms. In this manuscript, we provide an update on the genetic basis of the most frequent types of DHRs, including those mediated by immunological and nonimmunological mechanisms. For the first group, we will focus on immediate reactions to β-lactam antibiotics, which are associated mainly with the IgE pathway (IL13, IL4R, LGALS3, and NOD2) and antigen presentation (HLA-DRA), and nonimmediate reactions to allopurinol, anticonvulsants, antibiotics, and antiretrovirals, which are often associated with polymorphisms in the HLA system. For the second group, we will focus on nonsteroidal anti-inflammatory drugs, which are mostly associated with genetic variants in enzymes and receptors from the arachidonic acid pathway (eg, ALOX5, ALOX5AP, PTGDR, and CYSLTR1). The information provided here will be of interest for medical practitioners from a range of disciplines who come across these reactions in their clinical practice, as well as for allergologists. Key words: Drug hypersensitivity. Immunologically-mediated reactions. Cross-hypersensitivity. Single-nucleotide polymorphisms. Genomewide association study. ResumenLas reacciones de hipersensibilidad a fármacos (RHFs) son respuestas no predecibles que se producen en algunos sujetos y que representan un serio problema de salud pública debido al número de pacientes implicados y a su potencial gravedad. Además de factores ambientales, en estas reacciones también participan factores genéticos, cuya influencia está, en la mayoría de los casos, aún por dilucidar. En este manuscrito describiremos la información disponible sobre la base genética de los tipos más frecuentes de RHFs, tanto de las mediadas inmunológicamente como de aquellas en las que no se requiere reconocimiento antigénico. En el primer grupo nos ocuparemos de las reacciones inmediatas a antibióticos β-lactámicos, que han sido asociadas con variantes relacionadas con la IgE (IL13, IL4R, LGALS3 y NOD2) y la presentación antigénica (HLA-DRA), y de las reacciones no inmediatas a diferentes grupos de medicamentos (alopurinol, anticonvulsivos, antibióticos y antiretrovirales), relacionadas fundamentalmente con polimorfismos en el sistema HLA. En el segundo grupo nos centraremos en las reacciones inducidas por antiinflamatorios no esteroideos (AINE), que han sido asociadas básicamente con variantes en enzimas y receptores de la vía del ácido araquidónico (ALOX5, ALOX5AP, PTGDR y CYSLTR1, entre otros). Esta revisión puede ser de interés no sólo para alergólogos, sino para los profesionales de otras ...

show abstract

Section: Beyond the Candidate Gene Approachmentioning

confidence: 99%

“…Suggestive associations were found for 3 genetic clusters in the Spanish group (RIMS1, BICC1, and RAD51L1) and 1 region in the Han Chinese group (ABI3BP). Most of these regions are linked to the Ca2 + , cAMP, and/or P53 signaling pathways [129].…”

Section: Beyond the Candidate Gene Approachmentioning

confidence: 99%

Update on the Genetic Basis of Drug Hypersensitivity Reactions

Jurado‐Escobar¹,

Perkins²,

García‐Martín³

et al. 2017

J Investig Allergol Clin Immunol

View full text Add to dashboard Cite

show abstract

“…Studies that have assessed the genetic variants potentially associated with immediate-type hypersensitivity to NSAIDs were predominantly conducted in Spain (41)(42)(43)(44)(45)(46)(47)(48). They reported an association with genes belonging to HLA genes (HLA-DRB1, HLA-B44, and HLA-Cw5) (43,44) or to the arachidonic acid pathway (ALOX5, ALOX5AP, ALOX15, TBXAS1, PTGDR, and CYSLTR1) (46, 49) ( Table 3).…”

Section: Genetic Predictors Of Nar To Nsaids Including Aspirinmentioning

confidence: 99%

“…A case-control study evaluated the histamine-producing pathway and showed a weak association with the diamine oxidase gene (DAO) (43). Only one study used a GWAS approach and suggested the potential implication of the CEP68 gene (encoding centrosomal protein of 68 KDa) in the development of hypersensitivity reactions to NSAIDs (48).…”

Section: Genetic Predictors Of Nar To Nsaids Including Aspirinmentioning

confidence: 99%

See 1 more Smart Citation

Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review

Oussalah

Mayorga

Blanca

et al. 2016

Allergy

View full text Add to dashboard Cite

Drug hypersensitivity includes allergic (AR) and nonallergic reactions (NARs) influenced by genetic predisposition. We performed a systematic review of genetic predictors of IgE-mediated AR and NAR with MEDLINE and PubMed search engine between January 1966 and December 2014. Among 3110 citations, the search selected 53 studies, 42 of which remained eligible. These eligible studies have evaluated genetic determinants of immediate reactions (IR) to beta-lactams (n = 19), NAR against aspirin (n = 12) and other nonsteroidal anti-inflammatory drugs (NSAIDs) (n = 8), and IR to biologics (n = 3). We reported two genomewide association studies and four case-control studies on candidate genes validated by replication. Genes involved in IR to beta-lactams belonged to HLA type 2 antigen processing, IgE production, atopy, and inflammation, including 4 genes validated by replications, HLA-DRA, ILR4, NOD2, and LGALS3. Genes involved in NAR to aspirin belonged to arachidonic acid pathway, membranespanning 4A gene family, histamine production pathway, and pro-inflammatory cytokines, while those involved in NAR to all NSAIDs belonged to arachidonic acid pathway and HLA antigen processing pathway. ALOX5 was a common predictor of studies on NAR to both aspirin and NSAIDs. Although these first conclusions could be drawn, this review highlights also the lack of reliable data and the need for replicating studies in contrasted populations, taking into account worldwide allele frequencies, gene-gene interactions, and contrasted situations of environmental exposure.Allergy 71 (2016) 443-462

show abstract

Clinical Association Between Pharmacogenomics and Adverse Drug Reactions

Zhou

Chen

Sneed

et al. 2015

Drugs

View full text Add to dashboard Cite

Adverse drug reactions (ADRs) are a major public health concern and cause significant patient morbidity and mortality. Pharmacogenomics is the study of how genetic polymorphisms affect an individual's response to pharmacotherapy at the level of a whole genome. This article updates our knowledge on how genetic polymorphisms of important genes alter the risk of ADR occurrence after an extensive literature search. To date, at least 244 pharmacogenes identified have been associated with ADRs of 176 clinically used drugs based on PharmGKB. At least 28 genes associated with the risk of ADRs have been listed by the Food and Drug Administration as pharmacogenomic biomarkers. With the availability of affordable and reliable testing tools, pharmacogenomics looks promising to predict, reduce, and minimize ADRs in selected populations.

show abstract

Genome-Wide Association Study in NSAID-Induced Acute Urticaria/Angioedema in Spanish and Han Chinese Populations

Abstract: The associations described were different from those related to the metabolism of arachidonic acid and could provide new mechanisms underlying NSAID-induced AUA.

Cited by 32 publications

References 70 publications

Update on the Genetic Basis of Drug Hypersensitivity Reactions

Update on the Genetic Basis of Drug Hypersensitivity Reactions

Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review

Clinical Association Between Pharmacogenomics and Adverse Drug Reactions

Contact Info

Product

Resources

About