Genome-Wide Association Study in Asians Identifies Novel Loci for High Myopia and Highlights a Nervous System Role in Its Pathogenesis

Association of Extracellular Signal-Regulated Kinase Genes With Myopia: A Longitudinal Study of Chinese Children

“…Our finding that RASGRF1 rs6495367 is significantly related to hypermetropic SE is consistent with the findings of a previous GWAS meta-analysis involving 160,420 Asian and European individuals ( Tedja et al, 2018 ). In another GWAS involving 3,269 Japanese participants, the association between RASGRF1 and myopia was confirmed ( Meguro et al, 2020 ). Recent studies have hypothesized that RASGRF1 is linked to the dopaminergic system ( Gong et al, 2017 ).…”

Genetic Association Study Revealed Three Loci Were Associated Risk of Myopia Among Minors

“…To date, a series of GWASs have been conducted to characterize the molecular mechanism responsible for myopia worldwide. 11,[15][16][17][18][19][20] However, not all could be replicated. For example, Wang et al 21 replicated findings of two Japanese GWAS in a Chinese population, and got null results.…”

“…[6][7][8][9][10] Recently, a genome-wide association study (GWAS) identified six novel loci (rs2246661, rs74633073, rs76903431, rs698047, rs17029206, and rs72748160) in Asian adults, and revealed the important role of genes in the nervous system in the pathogenesis of myopia. 11 The findings highlighted a nervous system role in pathogenesis of myopia. Minors are better suited to studying the genetic factors of myopia.…”

The Slowly Emerging Uniqueness of the High Myopia Genetic Architecture

“…(Magnified version of Fig A-H is available online at www.aaojournal.org). ANTOINE ROUSSEAU, MD, PHD 1 JEAN-MARIE MICHOT, MD 2 MARC LABETOULLE, MD, PHD 1…”

“…Tracing genetic mechanisms that regulate emmetropization, but are disrupted in refractive error may cast light on the pathogenesis of myopia and inspire new effective prevention or therapeutic strategies. Rising to this challenge, Meguro et al 1 (see page 1612) report the results of a genome-wide association study of high myopia in subjects of East Asian origin. This study seeks to establish statistical correlations between high myopia and the presence of genetic polymorphisms (small and commonly encountered variations in the DNA sequence).…”