Genome-wide association study identifies 30 obsessive-compulsive disorder associated loci
Nora I. Strom,
Zachary F. Gerring,
Marco Galimberti
et al.
Abstract:Obsessive-compulsive disorder (OCD) affects ∼1% of the population and exhibits a high SNP-heritability, yet previous genome-wide association studies (GWAS) have provided limited information on the genetic etiology and underlying biological mechanisms of the disorder. We conducted a GWAS meta-analysis combining 53,660 OCD cases and 2,044,417 controls from 28 European-ancestry cohorts revealing 30 independent genome-wide significant SNPs and a SNP-based heritability of 6.7%. Separate GWAS for clinical, biobank, … Show more
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