Genome-Wide Association Study (Gwas) Identifies Candidate Neurotoxicity Markers in Platinum-Taxane Treated Ovarian Cancer Patients in Icon7

Espin‐Garcia, Osvaldo; Liu, G.; Owzar, Kouros; Kroetz, Deanna L.; Marsh, Sharon; Perrin, Thomas; Adusei, Cybil; Farrelly, Laura; Embleton, Andrew C.; Swart, Ann Marie; Parmar, Mahesh; Kaplan, Richard; Kubo, Michiaki; Ratain, Mark J.; Matsuda, Koichi; Oza, A.M.; Xu, Wei; Mackay, Helen

doi:10.1093/annonc/mdu326.14

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“…The dissolved flux was calculated by multiplying the river flow rate with the river Ra activity. The Ra activities in the Pearl River (Wang, 2014) and Yangtze River (Su et al, 2015) were the sum of the dissolved Ra and 40% of the Ra carried in suspension at the river mouth (Gu et al, 2012). The riverine 226 Ra flux was calculated to be 2.3 3 10 11 and 6.5 3 10 11 dpm d 21 , accounting for 6.6% and 8.5% of the total 226 Ra flux to the WPRE and ECS box model, respectively.…”

Section: Sgd Fluxes Estimated Using Box Modelsmentioning

confidence: 99%

“…Similarly, a three end-member mixing model was established in ECS, with three potential endmembers, Yangtze River plume (YRP), offshore surface water (OSW), and SGD (Figures 4e and 4f). Endmember values for the Yangtze River water were from literature (Su et al, 2015). The value for the SGD endmember is the mean value in groundwater samples, assuming the beach groundwater represents the composition of all SGD entering the near-shore waters.…”

Section: Sgd Fluxes Derived From Three End-member Mixing Modelmentioning

confidence: 99%

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Shelf‐Scale Submarine Groundwater Discharge in the Northern South China Sea and East China Sea and its Geochemical Impacts

et al. 2018

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To evaluate biogeochemical impacts of shelf‐scale submarine groundwater discharge (SGD), the northern South China Sea (NSCS) and the East China Sea (ECS) shelf were chosen for this study. Based on a three end‐member mixing model and a Ra box model, SGD fluxes on NSCS (west and east of the Pearl River Estuary, WPRE and EPRE, respectively) and ECS shelf in winter were estimated to be 3.8–9.5 × 109, 1.4–2.2 × 109 and 0.7–2.2 ×1010 m3 d−1, respectively. Our results were equivalent to the SGD flux to the entire Mediterranean Sea, and were an order of magnitude greater than fluxes to the South Atlantic Bight. SGD associated nutrient fluxes into WPRE, EPRE and ECS were almost in the same order of magnitude, 0.2–2.4 × 103 mol m−1 d−1 for dissolved inorganic nitrogen, 1.2–9.8 mol m−1 d−1 for soluble reactive phosphorus, and 0.4–3.4 × 103 mol m−1 d−1 for dissolved silicate. Moreover, SGD delivered 1.1–2.8 × 104, 0.6–0.9 × 104, 1.7–5.1 × 104 mol m−1 d−1 dissolved inorganic carbon and 1.1–2.7 × 104, 0.5–0.8 × 104, 1.6–4.8 × 104 mol m−1 d−1 total alkalinity to WPRE, EPRE and ECS, respectively. Shelf‐scale SGD is a significant source of nutrients and carbon, and may pose great impacts on regional marine ecosystems.

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Section: Sgd Fluxes Estimated Using Box Modelsmentioning

confidence: 99%

Section: Sgd Fluxes Derived From Three End-member Mixing Modelmentioning

confidence: 99%