“…For example, of 19 loci identified, five were associated with BMI / obesity (FTO, MC4R, TFAP2B, NRXN3, MSRA) [20,58,59]. Additional likely causative genes for extreme obesity include TMEM18, NPC1, PTER, PRL and SDCCAG8 [20,60,61]. The biological role of several candidate genes for obesity (e.g., FTO, MC4R, POMC, SH2B1, BDNF, NPC1, NRX3 and NEGR1) [20,21] involve adipose tissue development and function or are known to act at the brain level indicating a role in regulation of eating behavior, hyperphagia and food intake.…”