Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan
Jai-Sing Yang,
Ting-Yuan Liu,
Hsing-Fang Lu
et al.
Abstract:Psoriasis is a chronic inflammatory dermatological disease, and there is a lack of understanding of the genetic factors involved in psoriasis in Taiwan. To establish associations between genetic variations and psoriasis, a genome-wide association study was performed in a cohort of 2,248 individuals with psoriasis and 67,440 individuals without psoriasis. Using the ingenuity pathway analysis software, biological networks were constructed. Human leukocyte antigen (HLA) diplotypes and haplotypes were analyzed usi… Show more
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