Genome-wide association studies of 27 accelerometry-derived physical activity measurements identified novel loci and genetic mechanisms

Gao, Qi; Dutta, Diptavo; Leroux, Andrew; D, Ray; Muschelli, John; Crainiceanu, Ciprian M.; Chatterjee, Nilanjan

doi:10.1101/2021.02.15.21251499

Cited by 2 publications

(4 citation statements)

References 59 publications

(111 reference statements)

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“…Genome-wide association study (GWAS) data for accelerometermeasured PA was obtained from the UK Biobank (http://www.nealelab. is/uk-biobank) (Qi et al, 2022). The GWAS data involve 88,411 European ancestry participants (Qi et al, 2022).…”

Section: Data Sources and Single-nucleotide Polymorphisms Selection 2...mentioning

confidence: 99%

“…is/uk-biobank) (Qi et al, 2022). The GWAS data involve 88,411 European ancestry participants (Qi et al, 2022). The GWAS data were adjusted for age, sex, and the first 20 genetic principal components (Qi et al, 2022).…”

Section: Data Sources and Single-nucleotide Polymorphisms Selection 2...mentioning

confidence: 99%

“…The GWAS data involve 88,411 European ancestry participants (Qi et al, 2022). The GWAS data were adjusted for age, sex, and the first 20 genetic principal components (Qi et al, 2022). Two PA phenotypes were included in the current MR analysis as exposures, including light and moderate-tovigorous intensity.…”

Section: Data Sources and Single-nucleotide Polymorphisms Selection 2...mentioning

confidence: 99%

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The causal effect of physical activity intensity on COVID-19 susceptibility, hospitalization, and severity: Evidence from a mendelian randomization study

Zhang

Zhang²,

Feng³

et al. 2023

Front. Physiol.

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The protection of physical activity (PA) against COVID-19 is a rising research interest. However, the role of physical activity intensity on this topic is yet unclear. To bridge the gap, we performed a Mendelian randomization (MR) study to verify the causal influence of light and moderate-to-vigorous PA on COVID-19 susceptibility, hospitalization, and severity. The Genome-Wide Association Study (GWAS) dataset of PA (n = 88,411) was obtained from the UK biobank and the datasets of COVID-19 susceptibility (n = 1,683,768), hospitalization (n = 1,887,658), and severity (n = 1,161,073) were extracted from the COVID-19 Host Genetics Initiative. A random-effect inverse variance weighted (IVW) model was carried out to estimate the potential causal effects. A Bonferroni correction was used for counteracting. The problem of multiple comparisons. MR-Egger test, MR-PRESSO test, Cochran’s Q statistic, and Leave-One-Out (LOO) were used as sensitive analysis tools. Eventually, we found that light PA significantly reduced the risk of COVID-19 infection (OR = 0.644, 95% CI: 0.480–0.864, p = 0.003). Suggestive evidence indicated that light PA reduced the risks of COVID-19 hospitalization (OR = 0.446, 95% CI: 0.227 to 0.879, p = 0.020) and severe complications (OR = 0.406, 95% CI: 0.167–0.446, p = 0.046). By comparison, the effects of moderate-to-vigorous PA on the three COVID-19 outcomes were all non-significant. Generally, our findings may offer evidence for prescribing personalized prevention and treatment programs. Limited by the available datasets and the quality of evidence, further research is warranted to re-examine the effects of light PA on COVID-19 when new GWAS datasets emerge.

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Section: Data Sources and Single-nucleotide Polymorphisms Selection 2...mentioning

confidence: 99%

Section: Data Sources and Single-nucleotide Polymorphisms Selection 2...mentioning

confidence: 99%

Section: Data Sources and Single-nucleotide Polymorphisms Selection 2...mentioning

confidence: 99%

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The causal effect of physical activity intensity on COVID-19 susceptibility, hospitalization, and severity: Evidence from a mendelian randomization study

Zhang

Zhang²,

Feng³

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…Notably, among the six GWAS, one high-quality study leveraging accelerometer data from 91,105 participants from the UK Biobank is consistent with previous findings on the role played by the central nervous system in activity behaviors (42). Moreover, an updated analysis of the UK Biobank accelerometry sub-study further suggests that the blood and immune system can be associated with exercise (43).…”

Section: Exercise and Geneticsmentioning

confidence: 99%

Can genetics guide exercise prescriptions in osteoarthritis?

Espin‐Garcia

Baghel²,

Brar³

et al. 2022

Front. Rehabilit. Sci.

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Osteoarthritis (OA) is the most common form of arthritis and has a multifactorial etiology. Current management for OA focuses on minimizing pain and functional loss, typically involving pharmacological, physical, psychosocial, and mind-body interventions. However, there remain challenges in determining which patients will benefit most from which interventions. Although exercise-based interventions are recommended as first-line treatments and are known to be beneficial for managing both the disease and illness of OA, the optimal exercise “prescription” is unknown, due in part to our limited understanding of the precise mechanisms underlying its action. Here we present our perspective on the potential role of genetics in guiding exercise prescription for persons with OA. We describe key publications in the areas of exercise and OA, genetics and OA, and exercise and genetics, and point to a paucity of knowledge at the intersection of exercise, genetics, and OA. We suggest there is emerging evidence to support the use of genetics and epigenetics to explain the beneficial effects of exercise for OA. We identify missing links in the existing research relating to exercise, genetics, and OA, and highlight epigenetics as a promising mechanism through which environmental exposures such as exercise may impact OA outcomes. We anticipate future studies will improve our understanding of how genetic and epigenetic factors mediate exercise-based interventions to support implementation and ultimately improve OA patient care.

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Genome-wide association studies of 27 accelerometry-derived physical activity measurements identified novel loci and genetic mechanisms

Cited by 2 publications

References 59 publications

The causal effect of physical activity intensity on COVID-19 susceptibility, hospitalization, and severity: Evidence from a mendelian randomization study

The causal effect of physical activity intensity on COVID-19 susceptibility, hospitalization, and severity: Evidence from a mendelian randomization study

Can genetics guide exercise prescriptions in osteoarthritis?

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