Genome-wide association studies for reproductive seasonality traits in Rasa Aragonesa sheep breed

Martínez-Royo, A.; Alabart, J. L.; Sarto, P.; Serrano, M.; Crespo, Belén Lahoz; Folch, J.; Calvo, J.H.

doi:10.1016/j.theriogenology.2017.05.011

Cited by 16 publications

(15 citation statements)

References 54 publications

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“…In different studies, identifications of molecular functions and metabolic pathways for genetic loci associated with diseases or traits obtained from GWAS results were carried out [25,63]. We investigated the molecular functions and metabolic processes of the 57 genes identified as a result of the GWAS analysis.…”

Section: Gene Ontology and Metabolic Pathwaysmentioning

confidence: 99%

Genome-Wide Association Study Reveals Candidate Genes for Litter Size Traits in Pelibuey Sheep

Hernández-Montiel

Martínez-Núñez

Ramón-Ugalde

et al. 2020

Animals

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The Pelibuey sheep has adaptability to climatic variations, resistance to parasites, and good maternal ability, whereas some ewes present multiple births, which increases the litter size in farm sheep. The litter size in some wool sheep breeds is associated with the presence of mutations, mainly in the family of the transforming growth factor β (TGF-β) genes. To explore genetic mechanisms underlying the variation in litter size, we conducted a genome-wide association study in two groups of Pelibuey sheep (multiparous sheep with two lambs per birth vs. uniparous sheep with a single lamb at birth) using the OvineSNP50 BeadChip. We identified a total of 57 putative SNPs markers (p < 3.0 × 10−3, Bonferroni correction). The candidate genes that may be associated with litter size in Pelibuey sheep are CLSTN2, MTMR2, DLG1, CGA, ABCG5, TRPM6, and HTR1E. Genomic regions were also identified that contain three quantitative trait loci (QTLs) for aseasonal reproduction (ASREP), milk yield (MY), and body weight (BW). These results allowed us to identify SNPs associated with genes that could be involved in the reproductive process related to prolificacy.

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Section: Gene Ontology and Metabolic Pathwaysmentioning

confidence: 99%

Genome-Wide Association Study Reveals Candidate Genes for Litter Size Traits in Pelibuey Sheep

Hernández-Montiel

Martínez-Núñez

Ramón-Ugalde

et al. 2020

Animals

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“…Phenotypic seasonality data were obtained from a Rasa aragonesa sheep flock managed at an experimental farm ("Pardina de Ayés") owned by Oviaragón S.C.L., located in the Pre-Pyrenees (Ayés, Sabiñánigo, Huesca; North-Eastern Spain, 42° 29' 48.55" N 0° 23' 37.54", 790 m above sea level) and described in Martinez-Royo et al [20]. The experimental period lasted from January to August in 2012.…”

Section: Animal Resourcesmentioning

confidence: 99%

“…Management of the ewes is described in Martinez-Royo et al [20]. The ewes were handled in a single lot and subjected to the same management, nutrition and environmental conditions.…”

Section: Animal Resourcesmentioning

confidence: 99%

“…Three reproductive seasonality traits were considered and described in Martinez-Royo et al [20]. Briefly, the first was the total days of anoestrus (TDA) based on weekly individual plasma progesterone levels.…”

Section: Measurement Of Reproductive Seasonality Traitsmentioning

confidence: 99%

“…MTNR1A has been characterized in several breeds as a candidate gene and appears to play a key role in the control of photoperiodinduced seasonality mediated by circadian melatonin concentrations [15][16]. respectively, revealed several chromosomes and SNPs that could be implicated in this trait [19][20].…”

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confidence: 99%

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SNP rs403212791 in exon 2 of the MTNR1A gene is associated with reproductive seasonality in the Rasa aragonesa sheep breed

Calvo

Serrano²,

Martínez-Royo

et al. 2018

Theriogenology

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The aim of this study was to characterize and identify causative SNPs in the MTNR1A gene responsible for the reproductive seasonality traits in the Rasa aragonesa sheep breed. A total of 290 ewes (155, 84 and 51 mature, young and ewe lambs, respectively) from one flock were controlled from January to August. The following three reproductive seasonality traits were considered: the total days of anoestrus (TDA) and the progesterone cycling months (P4CM); both ovarian function seasonality traits based on blood progesterone levels; and the oestrus cycling months (OCM) based on oestrous detection, which indicate behavioural signs of oestrous. We have sequenced the total coding region plus 733 and 251 bp from the promoter and 3'-UTR regions, respectively, from the gene in 268 ewes. We found 9 and 4 SNPs associated with seasonality traits in the promoter (for TDA and P4CM) and exon 2 (for the three traits), respectively. The SNPs located in the gene promoter modify the putative binding sites for various trans-acting factors. In exon 2, two synonymous SNPs affect RFLP sites, rs406779174/RsaI (for the three traits) and rs430181568/MnlI (for OCM), and they have been related with seasonal reproductive activity in previous association studies with other breeds. SNP rs400830807, which is located in the 3'-UTR, was associated with the three traits, but this did not modify the putative target sites for ovine miRNAs according to in silico predictions. Finally, the SNP rs403212791 (NW_014639035.1: g.15099004G > A), which is also associated with the three seasonality phenotypes, was the most significant SNP detected in this study and was a non-synonymous polymorphism, leading a change from an Arginine to a Cysteine (R336C). Haplotype analyses confirmed the association results and showed that the effects found for the seasonality traits were caused by the SNPs located in exon 2. We have demonstrated that the T allele in the SNP rs403212791 in the MNTR1A gene is associated with a lower TDA and higher P4CM and OCM values in the Rasa Aragonesa breed.

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Detection of selection signatures in the genome of a farmed population of anadromous rainbow trout (Oncorhynchus mykiss)

Cádiz¹,

López²,

Díaz-Domínguez³

et al. 2021

Genomics

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Genome-wide association studies for reproductive seasonality traits in Rasa Aragonesa sheep breed

Cited by 16 publications

References 54 publications

Genome-Wide Association Study Reveals Candidate Genes for Litter Size Traits in Pelibuey Sheep

Genome-Wide Association Study Reveals Candidate Genes for Litter Size Traits in Pelibuey Sheep

SNP rs403212791 in exon 2 of the MTNR1A gene is associated with reproductive seasonality in the Rasa aragonesa sheep breed

Detection of selection signatures in the genome of a farmed population of anadromous rainbow trout (Oncorhynchus mykiss)

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